Abstract
The photoinduced carbon monoxide releasing properties of pyridylbenzimidazole‐based RuII–carbonyl complexes functionalized with alkylated sulfonate (LSO3H), phthalimide (LPhth), and morpholine (Lmorph) moieties, [RuCl(CO)3LSO3H]Cl (1) and [RuCl2(CO)2L] {where L = LPhth (2) and Lmorph (3)}, are reported. The geometrical stereochemistry and electronic transitions are assigned with the aid of DFT and TDDFT calculations. The compounds are evaluated for potential antimicrobial and cytotoxic active properties [against noncancerous human embryonic kidney cells (HEK293)]. Complex 2 shows interesting antifungal activity towards Candida albicans and Cryptococcus neoformans, with a similar MIC value of 24 nm. Metalation of hen egg‐white lysozyme (HEWL), as a biocompatible carrier, is studied in the dark and upon exposure to light. Stable protein adducts, capable of release CO upon illumination, are formed.
The photoinduced carbon monoxide releasing properties of selected ruthenium complexes are reported, together with their stereochemistry and electronic transitions. The compounds are evaluated for potential antimicrobial and cytotoxic active properties, with one compound showing antifungal activity. Metalation of hen egg‐white lysozyme yields photoactive CO‐releasing protein adducts.