Abstract
Coumarins have multiple biological activities; various coumarin-related derivatives are recognized as inhibitors of the lipoxygenase and cycloxygenase pathways of arachidonate metabolism. Several natural or synthetic coumarins with various hydroxyl and other substitutes were found to inhibit lipid peroxidation and to scavenge hydroxyl radical and superoxide anion and to influence processes involving free radical mediated injury. The heterocyclic derivatives of 3-formyl-4-hydoxycoumarin were found to present significant anti-inflammatory effect, the compounds inhibited formalin induced hind paw edema and they also significantly suppressed the formation of granuloma tissue in cotton pellet induced chronic model of inflammation. The result showed that the anti-inflammatory (both acute & chronic) effect of the test compound Ib is comparable to that of standard Antiinflammatory drug Diclofenac Sodium.