SIRT3 and cancer: Tumor promoter or suppressor?

Turki Y. Alhazzazi; Pachiyappan Kamarajan; Eric Verdin; Yvonne L. Kapila

doi:10.1016/j.bbcan.2011.04.004

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SIRT3 and cancer: Tumor promoter or suppressor?

Journal article

Open access

Peer reviewed

SIRT3 and cancer: Tumor promoter or suppressor?

Turki Y. Alhazzazi, Pachiyappan Kamarajan, Eric Verdin and Yvonne L. Kapila

Biochimica et biophysica acta. Reviews on cancer, Vol.1816(1), pp.80-88

01/08/2011

DOI: https://doi.org/10.1016/j.bbcan.2011.04.004

PMCID: PMC3129516

PMID: 21586315

Abstract

Cancer

SIRT3

Sirtuin-3

Tumor promoter

Tumor suppressor

Sirtuins (SIRT1–7), the mammalian homologues of the Sir2 gene in yeast, have emerging roles in age-related diseases, such as cardiac hypertrophy, diabetes, obesity, and cancer. However, the role of several sirtuin family members, including SIRT1 and SIRT3, in cancer has been controversial. The aim of this review is to explore and discuss the seemingly dichotomous role of SIRT3 in cancer biology with particular emphasis on its potential role as a tumor promoter and tumor suppressor. This review will also discuss the potential role of SIRT3 as a novel therapeutic target to treat cancer.

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Title: SIRT3 and cancer: Tumor promoter or suppressor?
Creators - without role: Turki Y. Alhazzazi - University of Michigan–Ann Arbor
Pachiyappan Kamarajan - University of Michigan–Ann Arbor
Eric Verdin - Gladstone Institutes
Yvonne L. Kapila - University of Michigan–Ann Arbor
Publication Details: Biochimica et biophysica acta. Reviews on cancer, Vol.1816(1), pp.80-88
Publisher: Elsevier B.V
Identifiers: 9940255408331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article