Abstract
In this paper, bifurcation of limit cycles from the infinity of a two-dimensional septic polynomial differential system is investigated. Sufficient and necessary conditions for the infinity to be a center are derived and the fact that there exist 16 large amplitude limit cycles bifurcated from the infinity is proved as well. The study relays on making use of a recursive formula for computing the singular point quantities of the infinity. As far as we know, this is the first example of a septic system with 16 limit cycles bifurcated from the infinity.