Abstract
Cholecystitis is a very common condition affecting the adults. It is more prevalent among females who consume high fat-diets. If not early and properly treated, cholecystitis may lead to gallbladder gangrene and necrosis. Therefore, early accurate diagnosis of the condition is fundamental. Diagnosis of acute cholecystitis depends on a combination of clinical presentation and radiological findings. The most useful and reliable test for diagnosis is abdominal ultrasonography, and the most sensitive and specific sonographic sign of acute cholecystitis. Sonographic Murphy sign refers to the presence of maximal tenderness over the right upper abdominal quadrant when the sonographer press with the ultrasound probe over this area to visualize the gall bladder. It has a good specificity, sensitivity, and positive predictive value particularly when combined with other signs such as cholelithiasis. The aim of this article is to review and discuss the use of sonographic Murphy's sign in suspected cases of acute cholecystitis.