Abstract
Two new ruthenium(III) complexes of 1st (cefradine) and 2nd (cefoxitin) generation of cephalosprin drugs have been synthesized and well characterized based on physical (molar conductance), spectral (FTIR & UV-Vis), thermal analysis (TGA & DTA) and analytical data. Both cefradine (ceph-1) and cefoxitin (ceph-2) act as a bidentate ligand and the synthesized complexes [Ru(L)(Cl)(2)(H2O)(2)] where [L=cefradine and cefoxitin] are showing octahedral geometry. The analytical data refer to 1:1 (Ru3+/ceph) stoichiometry. FTIR analysis confirmed the coordination through the two oxygen atoms of beta-lactam and carboxylate groups. The surface morphology and particle size investigations were evaluated using XRD, SEM and TEM analyses. The antimicrobial effect of ruthenium(III) ion upon complexity with ceph-1 and ceph-2 were assessed against Gram positive (Staphylococcus epidermidis & Staphylococcus aureus) and Gram negative (Klebsiella spp., Escherichia coli) bacterial strains. The potential anticancer properties of Ru3+ cephalosprin complexes were evaluated in vitro on colorectal adenocarcinoma (Caco-2) and breast cancer (MCF-7) cell lines, indicating that the synthesized Ru(III) complexes are relatively better cytotoxic agents in comparison with cisplatin standard drug.