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STEREOSELECTIVITY OF PHTHALIMIDO beta-LACTAMS FORMATION: SYNTHESIS OF 3-AMINO beta-LACTAMS THROUGH A FACILE DEPROTECTION REACTION
Journal article

STEREOSELECTIVITY OF PHTHALIMIDO beta-LACTAMS FORMATION: SYNTHESIS OF 3-AMINO beta-LACTAMS THROUGH A FACILE DEPROTECTION REACTION

Armando Paniagua, Ram Naresh Yadav, Sunena Chandra and Bimal Krishna Banik
Heterocyclic letters, Vol.8(2), pp.287-295
01/01/2018

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Synthesis of amino beta-lactams is a crucial objective because of the medicinal properties associated with them and the products derived from of them. Stereocontrolled synthesis of phthalimido beta-lactams is performed and cis and trans-phthalimido beta-lactams are deprotected with ethylene diamine (and other reagents) to amino beta-lactams of diverse structures in excellent yield. This reaction is also conducted under solventless conditions to afford identical products.

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