STUDIES ON α-[6-(2′-METHOXYNAPHTHALENYL)-4-PHENYLPYRIMIDINYLTHIO]-β/-(4-PHENYLBENZOYL)PROPIONIC ACID AND THE BIOLOGICAL ACTIVITY OF SOME PRODUCTS

M. M. H. Arief; S. A. Essawy; A. A. F. Wasfy; S. A. Nassar; A. A. Hashish

doi:10.1080/10426509408021928

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STUDIES ON α-[6-(2′-METHOXYNAPHTHALENYL)-4-PHENYLPYRIMIDINYLTHIO]-β/-(4-PHENYLBENZOYL)PROPIONIC ACID AND THE BIOLOGICAL ACTIVITY OF SOME PRODUCTS

Journal article

Peer reviewed

STUDIES ON α-[6-(2′-METHOXYNAPHTHALENYL)-4-PHENYLPYRIMIDINYLTHIO]-β/-(4-PHENYLBENZOYL)PROPIONIC ACID AND THE BIOLOGICAL ACTIVITY OF SOME PRODUCTS

M. M. H. Arief, S. A. Essawy, A. A. F. Wasfy, S. A. Nassar and A. A. Hashish

Phosphorus, sulfur, and silicon and the related elements, Vol.91(1-4), pp.1-7

01/06/1994

DOI: https://doi.org/10.1080/10426509408021928

Abstract

biological evaluation

Michael reaction

nitrogen nucleophiles

β-(4-phenylbenzoyl)acrylic acid I reacted with 6-(2′-methoxynaphthalenyl)-4-phenylpyrimidine-2(1H)thione to furnish α-[6-(2′-methoxynaphthalenyl)-4-phenylpyrimidinylthio]-β-(4-phenylbenzoyl)propionic acid II. Dehydration of acid II aforded furanone derivative III. The behaviour of III towards hydrazine hydrate, hydroxylamine hydrochloride, primary amines, aromatic hydrocarbons (under Friedel-Crafts conditions) and carbon nucleophiles (under Grignard conditions) has been investigated.

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Title: STUDIES ON α-[6-(2′-METHOXYNAPHTHALENYL)-4-PHENYLPYRIMIDINYLTHIO]-β/-(4-PHENYLBENZOYL)PROPIONIC ACID AND THE BIOLOGICAL ACTIVITY OF SOME PRODUCTS
Creators - without role: M. M. H. Arief - Benha University
S. A. Essawy - Benha University
A. A. F. Wasfy - Benha University
S. A. Nassar - Benha University
A. A. Hashish - Benha University
Publication Details: Phosphorus, sulfur, and silicon and the related elements, Vol.91(1-4), pp.1-7
Publisher: Taylor & Francis Group
Identifiers: 9926149708331
Academic Unit: Prince Sattam Bin Abdulaziz University
Language: English
Resource Type: Journal article