SYNTHESIS AND ANALGESIC ACTIVITY OF (2,3-DIPHENYL-1H-INDOL-5-YL)PIPERAZIN-1-YL METHANONE DERIVATIVES

A. O. H. El-Nezhawy; S. I. El-Naem; S. A. Galal; H. I. El-Diwani; O. M. E. Abdel Salam; A. R. Baiomy

doi:10.1007/s11094-009-0234-y

Back

SYNTHESIS AND ANALGESIC ACTIVITY OF (2,3-DIPHENYL-1H-INDOL-5-YL)PIPERAZIN-1-YL METHANONE DERIVATIVES

Journal article

Peer reviewed

SYNTHESIS AND ANALGESIC ACTIVITY OF (2,3-DIPHENYL-1H-INDOL-5-YL)PIPERAZIN-1-YL METHANONE DERIVATIVES

A. O. H. El-Nezhawy, S. I. El-Naem, S. A. Galal, H. I. El-Diwani, O. M. E. Abdel Salam and A. R. Baiomy

Pharmaceutical chemistry journal, Vol.43(1), pp.25-29

01/01/2009

DOI: https://doi.org/10.1007/s11094-009-0234-y

Abstract

Chemistry, Medicinal

Life Sciences & Biomedicine

Pharmacology & Pharmacy

Science & Technology

Series of 1,4-disubstituted piperazine and of N,N-disubstituted ethylenediamine having the 2,3-diphenyl-1H-indole-5-carbonyl group as one of the two substituents were prepared. Compounds 3, 4, 11, 15 - 17, and 20 - 22 were tested for analgesic activity. After ip administration all compounds induced significant visceral antinociceptive activities where acetic acid-induced writhing was significantly reduced by all compounds.

Metrics

1 Record Views

See more details

Details

Title: SYNTHESIS AND ANALGESIC ACTIVITY OF (2,3-DIPHENYL-1H-INDOL-5-YL)PIPERAZIN-1-YL METHANONE DERIVATIVES
Creators - without role: A. O. H. El-Nezhawy - Chemistry of Natural and Microbial Products Department, National Research Center, Cairo, Egypt
S. I. El-Naem - Chemistry of Natural and Microbial Products Department, National Research Center, Cairo, Egypt
S. A. Galal - Chemistry of Natural and Microbial Products Department, National Research Center, Cairo, Egypt
H. I. El-Diwani - Chemistry of Natural and Microbial Products Department, National Research Center, Cairo, Egypt
O. M. E. Abdel Salam - National Water Research Center
A. R. Baiomy - National Water Research Center
Publication Details: Pharmaceutical chemistry journal, Vol.43(1), pp.25-29
Publisher: Springer Nature
Number of pages: 5
Identifiers: 9910948408331
Academic Unit: Taif University
Language: English
Resource Type: Journal article