Abstract
A novel, facile reaction for the synthesis of series of thiazole derivatives has been developed from the reaction of the appropriate thiosemicarbazone derivatives and 2-bromo-1-(5-methyl-l-pheny1-1H-pyrazol-4-yl)ethanone in ethanol under reflux. The structures of the newly synthesized products were established on the basis of spectral data (mass, IR, H-1 and C-13 NMR) and elemental analyses. The pharmacological screening showed that many of the synthesized compounds exhibit a good antihypertensive a-blocking activity and having low toxicity, as compared to Minoxidil.