Abstract
Some novel substituted pyrazoles 4(a-t) were synthesized from hydrazone synthons 3(a-x) after reaction with hydrazine hydrate. The hydrazones 3(a-x) were afforded through coupling of their corresponding diazonium salts with ethyl cyanoacetate, malononitrile, acetyl acetone and ethyl acetoacetate, respectively. The antiviral activity of such compounds was evaluated against a wide set of viruses; adenovirus type 7, rotavirus, HSV-1 and HCV viruses in different cell lines. Amongst the tested compounds, 3(b), 3(h), 3(p), 3(w), 4(g), 4(q) and 4(r) showed significant antiviral activity. Compounds 4(g) and 4(r) particularly exhibited the highest activity of all the tested title compounds against all the study viruses. On the other hand, compounds 3(b), 3(h), 3(p), 4(g), 4(q) and 4(r) showed significant anti-HSV-1 activity. Hydrazones 3b and 3h showed moderate anti-HCV activity. Pyrazoles 4(q) and 4(r) showed moderate activity against adenovirus type-7. On the contrary, the title pyrazoles 4(a-t) showed no significant anti-HCV activity and the title hydrazones 3(a-x) had no significant antiviral activity against adenovirus type-7. Copyright (C) 2013 - All Rights Reserved - Pharmacophore