Abstract
A series of novel functionalized 1,3-selenazoles bearing 4-oxo-4H-chromen-3-yl moiety was constructed by Hantzsch-type condensation reaction. The methodology depended on the cyclization of N-[(4-oxo-4H-chromen- 3-yl)methylene]selenosemicarbazide with bis-halogen and alpha-halocarbonyl compounds in DMF. The structures of the synthesized compounds were assigned based on the spectral tools. The cytotoxicity properties of the products were evaluated. Both compounds 9 and 11 showed significant cytotoxic properties against HCT-116, Hep-G2, A-549 and MCF-7 cancer cell lines.