Abstract
A new series of 6- bromoquinazolin-4(3H)-one derivatives were synthesized. Their chemical structures were confirmed by spectral and elemental analysis. All synthesized compounds were tested in vita) against human breast cancer cell line (MCF-7). Compounds IIIc, Vb and IIIa exerted powerful cytotoxic activity with IC50 (0.236, 0.316 and 0.359 mu Ml/mL), respectively.