Abstract
Seventeen 7-hydroxy coumarin (umbelliferone) derivatives were synthesized in an almost quantitative yield via reaction with the corresponding ethylchloroacetate, p-substituted benzyl chloride, 2-bromoacetophenone or 2-chloroacetanilide in the presence of anhydrous potassium carbonate in dry acetone. The compounds were tested for their anti-inflammatory activity using cotton pellet implantation test and carrageenan-induced rat paw edema. The ulcerogenic effect of the compounds was also studied comparing with the NSAID indomethacin.