Abstract
The reaction of 2-pyridylacetophenone (2) with phenyl isothiocyanate gave thiocarbamoyl derivative 4 which on reaction with alpha-halocarbonyl compounds in a mixture of ethanol and N,N-dimethylformamide in the presence of triethylamine afforded thiophenes 6, 8, 10, 12 and 14 derivatives. While, when the same reaction was carried out in ethanol without N,N-dimethylformamide, it afforded the corresponding acyclic compounds 5, 7, 9, 11 and 13 which on reflux in N,N-dimethylformamide in the presence of triethylamine gave the corresponding thiophene derivatives. The newly synthesized compounds were characterized by analytical, spectral data and evaluated their antimicrobial activities. Compounds 6, 8, 10, 12, 13 and 14 were found to have high antimicrobial activities.