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SYNTHESIS OF 10-DEACETOXYTAXOL AND 10-DEOXYTAXOTERE
Journal article   Peer reviewed

SYNTHESIS OF 10-DEACETOXYTAXOL AND 10-DEOXYTAXOTERE

A G Chaudhary and DGI Kingston
Tetrahedron letters, Vol.34(31), pp.4921-4924
30/07/1993
DOI: https://doi.org/10.1016/S0040-4039(00)74046-9

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
10-Deacetoxytaxol (9) and 10-deoxytaxotere (10) have been prepared from 10-deacetylbaccatin III by attachment of the C-13 side-chain and deoxygenation. 10-Deacetoxytaxol is comparable to taxol in its cytotoxicity to P-388 cells, but 10-deoxytaxotere is significantly more cytotoxic than taxol.

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