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SYNTHESIS OF 2-AMINO-4-(2-HYDROXYNAPHTHYL)4H-CHROMENE-3-CARBONITRILES BY MICHAEL ADDITION AND THEIR TRANSFORMAION INTO NEW PENTACYCLIC COMPOUNDS
Journal article   Peer reviewed

SYNTHESIS OF 2-AMINO-4-(2-HYDROXYNAPHTHYL)4H-CHROMENE-3-CARBONITRILES BY MICHAEL ADDITION AND THEIR TRANSFORMAION INTO NEW PENTACYCLIC COMPOUNDS

Lamia Dammak, Myriam Kammoun, Houcine Ammar, Souhir Abid and Rachid El Gharbi
Synthetic communications, Vol.44(19), pp.2870-2878
02/10/2014

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
2-Amino-4-(2-hydroxynaphthyl)-4H-chromene-3-carbonitriles were synthesized by Michael addition of various 3-cyanoiminocoumarins and beta-naphthol in good yield. The heterocyclization of these materials in an acidic medium leads new heterocyclic compounds, which have not previously been described, in moderate to good yields and good selectivity. The synthesized compounds were characterized by infrared, H-1 NMR, C-13 NMR, two-dimensional NMR, and elemental analysis.

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