Abstract
A novel series of 9-substituted-chromeno[4',3':3,4]pyrrolo[2,1-c]-[1,2,4]triazole-6,7-diones (4), chromeno [4',3':3,4]pyrrolo [1,2-d]tetrazole-6,7-dione (5), 9-phenyl-6H- chromeno [4',3':3,4]pyrrolo[2,1-c][1,2,4]triazine-6,7 (11H)-dione (8), chromeno [4',3':3,4]pyrrolo [2,1-c][1,2,4]triazole-6,7,9(10H)-trione (10), (3,5-substituted-pyrazol-1-yl)chromeno[3,4-c]pyrrole-3,4-dione (15-19) and thiazole derivatives (28-37) were synthesized using 1-hydrazinylchromeno[3,4-c]-pyrrole-3,4-dione (2) as a precursor. The newly synthesized compounds were characterized and evaluated for their cytotoxic activity.