Abstract
On account of the interesting pharmacological properties of 2-thiohydantoin derivatives, and other purposes such as textile printing, catalysts for polymerizations, their uses in the production of resins and plastics, they have been the subject of chemical and biological studies. In this review article, we focused our interest on the most important methods for the synthesis of 2-thiohydantoin derivatives, different reactions and different applications of them. We explored their antitumor, antimicrobial, antidiabetic, anticonvulsant activities, their utilities in treatment of vascular dysfunction and, using them as an inhibitor of fatty acid amide hydrolase.