Abstract
The aim of this investigation is to evaluate the values of salivary fluid from biochemical estimation, nitrogen analysis and antioxidants represent promising tool for the research of oral in four groups. The first group contains 25 healthy persons (no history of tobacco and alcohol) considered as control, the second group contains 25 people with oral cancer, the third group contains 25 people with kidney failure or chronic kidney diseases (CKD) and the fourth group contains 25 smoker people.
From the results, it could be noticed that the mean kidney function concentrations in saliva were higher in CKD group followed by oral cancer and smoker groups than healthy control group. The nitrogen analyses were high by 60%, 190%, and 93%, respectively, in the oral cancer patients. Moreover, in the kidney failure patients, these salivary values were increased to 66.9, 207.13 and 117.55%, respectively in comparison to healthy control. Smoker People increased to 19.86, 27.13 and 13.03%, respectively compared healthy control.
The determination of antioxidant capacity (ImAx) had significant reduction by 22, 16 and 3.8% in oral cancer patients, CKD patients and in the smokers, respectively. Whereas, the total antioxidants had 49, 39 and 8.16% reduction in the same groups, respectively. Similarly, the peroxidase activity, glutathione S-transferase (GST) activity and superoxide dismutase (SOD) activity of enzymes as antioxidant in salivary were reduced by 27.46, 30 and 28% in oral cancer patients. Moreover, in kidney failure, patients were reduced by 20.98, 23.9 and 21.6%, respectively. Whereas, in smokers reduced by 8.29, 10.87 and11.2%, respectively than healthy control.
Findings of this investigation with regard to evaluation of the salivary fluid in biochemical estimation, nitrogen analysis and antioxidants in oral carcinoma, chronic kidney disease and smokers could be beneficial to diagnose underlying disease.