Abstract
Background: Unless vaccines are approved and widely used, there will be over 400 million cases of coronavirus illness (COVID-19) in 2019. This is less than two years after the World Health Organization called it a pandemic. Vaccines, on the other hand, may have individual-level side effects that warrant additional research. Objective: The study's aim was to identify the adverse effects reported by the Saudi population in relation to the COVID-19 vaccines. Methodology: A cross-sectional observational study was held in Saudi Arabia between March 1, 2022, and April 15, 2022. Results: The study comprised 3463 adults ranging in age from 18 to 94 years old, with an average age of 33.4 years. The type of vaccine had a statistically significant association with fever, joint pain, lower limb edema, nausea, abdominal discomfort, sweating, distal limb tingling, vertigo), chest pain, sleepiness or drowsiness, and arrhythmia or tachycardia. Conclusion: The lower incidence of fever, joint discomfort, lower limb edema, nausea, abdominal pain, sweating, distal limb tingling, vertigo, drowsiness, and tachycardia were associated with Pfizer vaccine. Lower incidences of chest pain were associated with AstraZeneca vaccine.