Abstract
New series of selenolo[2,3-
c]pyridazine and pyrimido[4′,5′:4,5]selenolo[2,3-
c] pyridazine derivatives were prepared from new 4-cyano-5,6-diphenylpyridazine-3(2
H)selenone (
2). Elemental analysis, IR,
1H NMR,
13C NMR and mass spectral data confirmed the structure of the newly synthesized compounds. Some selected compounds
2,
4a,
b,
6a–
c, and
11a were investigated for their anti-inflammatory activity. Compounds
4b and
6a–
c which showed activity comparable to the standard drug Indomethacin were screened for their analgesic activity. In addition, the most active compounds were tested for their acute toxicity. Moreover, some of the tested compounds
4b,
6a,
6b and
6c were screened for their antibacterial and antifungal activities.
New series of selenolo[2,3-
c]pyridazine and pyrimido[4′,5′:4,5]selenolo[2,3-
c] pyridazine derivatives were prepared from new 4-cyano-5,6-diphenylpyridazine-3(2
H)selenone (
2).
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