Self-Assembled Metal-Organic Complexes for Thermally Reversible Permeabilization of Cell Membranes

Safaa Al-Rehili; Mram Alyami; Yang Zhang; Basem Moosa; Peng Yang; Kholod Alamoudi; Siba Alharbi; Ohoud Alharbi; Rachid Sougrat; Abdulaziz AlMalik; Niveen M. Khashab

doi:10.1021/acsabm.8b00720

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Self-Assembled Metal-Organic Complexes for Thermally Reversible Permeabilization of Cell Membranes

Journal article

Peer reviewed

Self-Assembled Metal-Organic Complexes for Thermally Reversible Permeabilization of Cell Membranes

Safaa Al-Rehili, Mram Alyami, Yang Zhang, Basem Moosa, Peng Yang, Kholod Alamoudi, Siba Alharbi, Ohoud Alharbi, Rachid Sougrat, Abdulaziz AlMalik, …

ACS applied bio materials, Vol.2(3), pp.970-974

18/03/2019

DOI: https://doi.org/10.1021/acsabm.8b00720

PMID: 35021386

Abstract

Materials Science

Materials Science, Biomaterials

Nanoscience & Nanotechnology

Science & Technology

Science & Technology - Other Topics

Technology

Natural and synthetic membrane active molecules increase the permeability of cell membranes. This can help cells combat multidrug efflux pumps as well as improve signaling and transfection. In this work, thermoresponsive metal-organic complexes (MOCs) have been constructed to transport cell impermeable cargo across the membrane through a poreaiding assembly. These MOCs can be reversibly controlled as they collapse when the temperature is increased and are simultaneously regenerated when the system is cooled down to room temperature. These ON/OFF molecular valves can be potentially used to overcome multidrug resistance (MDR) in cancer cells and as building blocks for artificial cells.

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Title: Self-Assembled Metal-Organic Complexes for Thermally Reversible Permeabilization of Cell Membranes
Creators - without role: Safaa Al-Rehili - King Abdullah Univ Sci & Technol KAUST, Smart Hybrid Mat SHMs Lab, Adv Membranes & Porous Mat Ctr, Thuwal 239556900, Saudi Arabia
Mram Alyami - King Abdullah Univ Sci & Technol KAUST, Smart Hybrid Mat SHMs Lab, Adv Membranes & Porous Mat Ctr, Thuwal 239556900, Saudi Arabia
Yang Zhang - King Abdullah Univ Sci & Technol KAUST, Smart Hybrid Mat SHMs Lab, Adv Membranes & Porous Mat Ctr, Thuwal 239556900, Saudi Arabia
Basem Moosa - King Abdullah Univ Sci & Technol KAUST, Smart Hybrid Mat SHMs Lab, Adv Membranes & Porous Mat Ctr, Thuwal 239556900, Saudi Arabia
Peng Yang - King Abdullah Univ Sci & Technol KAUST, Smart Hybrid Mat SHMs Lab, Adv Membranes & Porous Mat Ctr, Thuwal 239556900, Saudi Arabia
Kholod Alamoudi - King Abdullah Univ Sci & Technol KAUST, Smart Hybrid Mat SHMs Lab, Adv Membranes & Porous Mat Ctr, Thuwal 239556900, Saudi Arabia
Siba Alharbi - King Abdullah Univ Sci & Technol KAUST, Smart Hybrid Mat SHMs Lab, Adv Membranes & Porous Mat Ctr, Thuwal 239556900, Saudi Arabia
Ohoud Alharbi - King Abdullah Univ Sci & Technol KAUST, Core Labs, Thuwal 239556900, Saudi Arabia
Rachid Sougrat - King Abdullah Univ Sci & Technol KAUST, Core Labs, Thuwal 239556900, Saudi Arabia
Abdulaziz AlMalik - King Abdulaziz City for Science and Technology
Niveen M. Khashab - King Abdullah Univ Sci & Technol KAUST, Smart Hybrid Mat SHMs Lab, Adv Membranes & Porous Mat Ctr, Thuwal 239556900, Saudi Arabia
Publication Details: ACS applied bio materials, Vol.2(3), pp.970-974
Publisher: Amer Chemical Soc
Number of pages: 5
Grant note: King Abdullah University of Science and Technology (KAUST); King Abdullah University of Science & Technology
Identifiers: 9919008308331
Academic Unit: King Abdulaziz City for Science & Technology; King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article