Abstract
The present research work explored the prospective of self-nanoemulsifying drug delivery system (SNEDDS) to improve the oral bioavailability of NBT and its anti-inflammatory effect. Nabumetone (NBT) is a poorly aqueous soluble drug that demonstrates low bioavailability after oral administration. NBT-SNEDDS was prepared by using Capryol-90, Tween-80 and polyethylene glycol-400 (PEG-400) via pseudo-ternary phase diagram. Different components of SNEDDS were curtained and found an optimal ratio of 22: 16:4:58 for Capryol-90, Tween-80, PEG-400 and deionized water, respectively. The developed SNEDDS were characterized in terms of physicochemical, drug release (via dialysis membrane) studies. The pharmacokinetics and anti-inflammatory activity of the drug from optimized NBT-SNEDDS was compared with the suspension of marketed tablet in rats. A high oral bioavailability (3.02-times) of the drug was found from SNEDDS as compared to the suspension of marketed tablet. Remarkably, NBT-SNEDDS presented an increased anti-inflammatory efficacy when compared with orally administered commercial product of NBT. The results indicated that NBT-SNEDDS could be a potential carrier for an oral dosage form of NBT with enhanced relative bioavailability and therapeutic effects.
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•Nabumetone (NBT) loaded self-nanoemulsifying drug delivery systems (SNEDDS) were developed via pseudo-ternary phase diagram technique to get larger zones of nanoemulsion/SNEDDS.•The droplet size of SNEDDS were found in the nanometer range by differential light scattering (DLS) measurement.•Physiological characterization and thermodynamic stability suggested the success of the developed SNEDDS.•In vitro release studies of the SNEDDS indicated the superior release profile of NBT as compared to the suspension of NILTIS® tablet.•The confocal laser microscopy indicated good permeation of the SNEDDS in to intestinal layer of rats.•In vivo PK-profiling and pharmacodynamics indicated the improved oral bioavailability and better anti-inflammatory effect of NBT from SNEDDS, respectively in rats.