Abstract
Promoting the differentiation of osteoblasts is critical to maintain bone homeostasis for treatment osteoporosis and fracture healing. For these orthopedic diseases, a portable, highly patient compliance therapy device remains a great challenge. Here, we proposed a biomechanical-energy-driven shape memory piezoelectric nanogenerator (sm-PENG) that integrated with fixation splint to promote osteogenic differentiation. The pulsed direct current (DC) generated from the sm-PENG effectively promote MC3T3-E1 preosteoblast cell proliferation, orientation and increase intracellular calcium ion. At the same time, the ALP activity of cells is also improved by pulsed-DC under long-term culture conditions. Ultimately, increasing calcium deposition, extracellular matrix mineralization and osteogenesis. Our work demonstrates the potential of sm-PENG as a power source for pulsed-DC stimulation of bone repair, and shows great prospect self-powered and portable electronic medical device.
An integrated self-powered pulsed-DC stimulation device based on shape memory piezoelectric nanogenerator with arch structure and fracture fixation splint used for bone repair. [Display omitted]
•A shape-memory piezoelectric nanogenerator (sm-PENG) integrated with fixation splint was proposed with good flexibility.•The sm-PENG is fabricated by thermo forming technology. This novel structure can better meet the requirement of therapy.•The effect of self-powered pulsed direct current stimulation can enhance osteogenesis was studied for the first time.