Abstract
Gold nanoparticles (AuNps) are often employed in different detection paths based on the catalytic growth mechanism; AuNps could act as catalyst for the reduction of AuCl4- and result in the enlargement of the original AuNps. However, there are few probes based on the anti-catalytical growth of AuNps in previous studies. In this article, we proposed a simple colorimetric sensor for the detection of glutathione (GSH) based on the anti-catalytical growth of AuNps, the strong affinity of GSH make it readily combine with AuNps or metal ions (AuCl4-), and thus inhibit the catalytical growth of AuNps through the specific property of GSH. Therefore, the UV absorbance of detection system could be used to estimate the concentration of GSH, and the probe exhibits highly sensitive and selective detection of the concentration of GSH with a wide linear from 13 to 800 nM within 20min. Meanwhile, a good linear relationship with correlation coefficient of R-2=0.9795 was obtained. It is believed that this research could broaden the choices of GSH detection methods.