Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Miles Parkes; Jeffrey C Barrett; Natalie J Prescott; Mark Tremelling; Carl A Anderson; Sheila A Fisher; Roland G Roberts; Elaine R Nimmo; Fraser R Cummings; Dianne Soars; Hazel Drummond; Charlie W Lees; Saud A Khawaja; Richard Bagnall; Denis A Burke; Catherine E Todhunter; Tariq Ahmad; Clive M Onnie; Wendy McArdle; David Strachan; Graeme Bethel; Claire Bryan; Cathryn M Lewis; Panos Deloukas; Alastair Forbes; Jeremy Sanderson; Derek P Jewell; Jack Satsangi; John C Mansfield; Lon Cardon; Christopher G Mathew; Wellcome Trust Case Control Consor

doi:10.1038/ng2061

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Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Journal article

Peer reviewed

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Miles Parkes, Jeffrey C Barrett, Natalie J Prescott, Mark Tremelling, Carl A Anderson, Sheila A Fisher, Roland G Roberts, Elaine R Nimmo, Fraser R Cummings, Dianne Soars, …

Nature genetics, Vol.39(7), pp.830-832

01/07/2007

DOI: https://doi.org/10.1038/ng2061

PMID: 17554261

Abstract

A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 × 10−4, combined P = 2.1 × 10−10) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.

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Title: Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
Creators - without role: Miles Parkes - University of Cambridge
Jeffrey C Barrett - University of Oxford
Natalie J Prescott - King's College London
Mark Tremelling - Addenbrooke's Hospital
Carl A Anderson - University of Oxford
Sheila A Fisher - King's College London
Roland G Roberts - King's College London
Elaine R Nimmo - University of Edinburgh
Fraser R Cummings - University of Oxford
Dianne Soars - King's College London
Hazel Drummond - University of Edinburgh
Charlie W Lees - Western General Hospital
Saud A Khawaja - King's College London
Richard Bagnall - King's College London
Denis A Burke - Royal Victoria Infirmary
Catherine E Todhunter - Royal Victoria Infirmary
Tariq Ahmad - University of Oxford
Clive M Onnie - King's College London
Wendy McArdle - University of Bristol
David Strachan - St George's, University of London
Graeme Bethel - Wellcome Sanger Institute
Claire Bryan - Wellcome Sanger Institute
Cathryn M Lewis - King's College London
Panos Deloukas - Wellcome Sanger Institute
Alastair Forbes - University College London Hospitals NHS Foundation Trust
Jeremy Sanderson - Guy's and St Thomas' NHS Foundation Trust
Derek P Jewell - University of Oxford
Jack Satsangi - University of Edinburgh
John C Mansfield - Newcastle University
Lon Cardon - Wellcome Centre for Human Genetics
Christopher G Mathew - King's College London
Wellcome Trust Case Control Consor
Publication Details: Nature genetics, Vol.39(7), pp.830-832
Identifiers: 9926444308331
Academic Unit: Prince Sattam Bin Abdulaziz University
Language: English
Resource Type: Journal article