Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Melissa A. Munn-Chernoff; Emma C. Johnson; Yi-Ling Chou; Jonathan R. I. Coleman; Laura M. Thornton; Raymond K. Walters; Zeynep Yilmaz; Jessica H. Baker; Christopher Hubel; Scott Gordon; Sarah E. Medland; Hunna J. Watson; Helena A. Gaspar; Julien Bryois; Anke Hinney; Virpi M. Leppa; Manuel Mattheisen; Stephan Ripke; Shuyang Yao; Paola Giusti-Rodriguez; Ken B. Hanscombe; Roger A. H. Adan; Lars Alfredsson; Tetsuya Ando; Ole A. Andreassen; Wade H. Berrettini; Ilka Boehm; Claudette Boni; Vesna Boraska Perica; Katharina Buehren; Roland Burghardt; Matteo Cassina; Sven Cichon; Maurizio Clementi; Roger D. Cone; Philippe Courtet; Scott Crow; James J. Crowley; Unna N. Danner; Oliver S. P. Davis; Martina de Zwaan; George Dedoussis; Daniela Degortes; Janiece E. DeSocio; Danielle M. Dick; Dimitris Dikeos; Christian Dina; Monika Dmitrzak-Weglarz; Elisa Docampo; Laramie E. Duncan; Karin Egberts; Stefan Ehrlich; Georgia Escaramis; Tonu Esko; Xavier Estivill; Anne Farmer; Angela Favaro; Fernando Fernandez-Aranda; Manfred M. Fichter; Krista Fischer; Manuel Foecker; Lenka Foretova; Andreas J. Forstner; Monica Forzan; Christopher S. Franklin; Steven Gallinger; Ina Giegling; Johanna Giuranna; Fragiskos Gonidakis; Philip Gorwood; Monica Gratacos Mayora; Sebastien Guillaume; Yiran Guo; Hakon Hakonarson; Konstantinos Hatzikotoulas; Joanna Hauser; Johannes Hebebrand; Sietske G. Helder; Stefan Herms; Beate Herpertz-Dahlmann; Wolfgang Herzog; Laura M. Huckins; James I. Hudson; Hartmut Imgart; Hidetoshi Inoko; Vladimir Janout; Susana Jimenez-Murcia; Antonio Julia; Gursharan Kalsi; Deborah Kaminska; Leila Karhunen; Andreas Karwautz; Martien J. H. Kas; James L. Kennedy; Anna Keski-Rahkonen; Kirsty Kiezebrink; Youl-Ri Kim; Kelly L. Klump; Gun Peggy S. Knudsen; Maria C. La Via; Stephanie Le Hellard; Robert D. Levitan; Dong Li; Lisa Lilenfeld; Bochao Danae Lin; Jolanta Lissowska; Jurjen Luykx; Pierre J. Magistretti; Mario Maj; Katrin Mannik; Sara Marsal; Christian R. Marshall; Morten Mattingsdal; Sara McDevitt; Peter McGuffin; Andres Metspalu; Ingrid Meulenbelt; Nadia Micali; Karen Mitchell; Alessio Maria Monteleone; Palmiero Monteleone; Benedetta Nacmias; Marie Navratilova; Ioanna Ntalla; Julie K. O'Toole; Roel A. Ophoff; Leonid Padyukov; Aarno Palotie; Jacques Pantel; Hana Papezova; Dalila Pinto; Raquel Rabionet; Anu Raevuori; Nicolas Ramoz; Ted Reichborn-Kjennerud; Valdo Ricca; Samuli Ripatti; Franziska Ritschel; Marion Roberts; Alessandro Rotondo; Dan Rujescu; Filip Rybakowski; Paolo Santonastaso; Andre Scherag; Stephen W. Scherer; Ulrike Schmidt; Nicholas J. Schork; Alexandra Schosser; Jochen Seitz; Lenka Slachtova; P. Eline Slagboom; Margarita C. T. Slof-Op't Landt; Agnieszka Slopien; Sandro Sorbi; Beata Swiatkowska; Jin P. Szatkiewicz; Ioanna Tachmazidou; Elena Tenconi; Alfonso Tortorella; Federica Tozzi; Janet Treasure; Artemis Tsitsika; Marta Tyszkiewicz-Nwafor; Konstantinos Tziouvas; Annemarie A. van Elburg; Eric F. van Furth; Gudrun Wagner; Esther Walton; Elisabeth Widen; Eleftheria Zeggini; Stephanie Zerwas; Stephan Zipfel; Andrew W. Bergen; Joseph M. Boden; Harry Brandt; Steven Crawford; Katherine A. Halmi; L. John Horwood; Craig Johnson; Allan S. Kaplan; Walter H. Kaye; James Mitchell; Catherine M. Olsen; John F. Pearson; Nancy L. Pedersen; Michael Strober; Thomas Werge; David C. Whiteman; D. Blake Woodside; Jakob Grove; Anjali K. Henders; Janne T. Larsen; Richard Parker; Liselotte V. Petersen; Jennifer Jordan; Martin A. Kennedy; Andreas Birgegard; Paul Lichtenstein; Claes Norring; Mikael Landen; Preben Bo Mortensen; Renato Polimanti; Jeanette N. McClintick; Amy E. Adkins; Fazil Aliev; Silviu-Alin Bacanu; Anthony Batzler; Sarah Bertelsen; Joanna M. Biernacka; Tim B. Bigdeli; Li-Shiun Chen; Toni-Kim Clarke; Franziska Degenhardt; Anna R. Docherty; Alexis C. Edwards; Jerome C. Foo; Louis Fox; Josef Frank; Laura M. Hack; Annette M. Hartmann; Sarah M. Hartz; Stefanie Heilmann-Heimbach; Colin Hodgkinson; Per Hoffmann; Jouke-Jan Hottenga; Bettina Konte; Jari Lahti; Marius Lahti-Pulkkinen; Dongbing Lai; Lannie Ligthart; Anu Loukola; Brion S. Maher; Hamdi Mbarek; Andrew M. McIntosh; Matthew B. McQueen; Jacquelyn L. Meyers; Yuri Milaneschi; Teemu Palviainen; Roseann E. Peterson; Euijung Ryu; Nancy L. Saccone; Jessica E. Salvatore; Sandra Sanchez-Roige; Melanie Schwandt; Richard Sherva; Fabian Streit; Jana Strohmaier; Nathaniel Thomas; Jen-Chyong Wang; Bradley T. Webb; Robbee Wedow; Leah Wetherill; Amanda G. Wills; Hang Zhou; Jason D. Boardman; Danfeng Chen; Doo-Sup Choi; William E. Copeland; Robert C. Culverhouse; Norbert Dahmen; Louisa Degenhardt; Benjamin W. Domingue; Mark A. Frye; Wolfgang Gabel; Caroline Hayward; Marcus Ising; Margaret Keyes; Falk Kiefer; Gabriele Koller; John Kramer; Samuel Kuperman; Susanne Lucae; Michael T. Lynskey; Wolfgang Maier; Karl Mann; Satu Maennistoe; Bertram Mueller-Myhsok; Alison D. Murray; John I. Nurnberger; Ulrich Preuss; Katri Raikkonen; Maureen D. Reynolds; Monika Ridinger; Norbert Scherbaum; Marc A. Schuckit; Michael Soyka; Jens Treutlein; Stephanie H. Witt; Norbert Wodarz; Peter Zill; Daniel E. Adkins; Dorret I. Boomsma; Laura J. Bierut; Sandra A. Brown; Kathleen K. Bucholz; E. Jane Costello; Harriet De Wit; Nancy Diazgranados; Johan G. Eriksson; Lindsay A. Farrer; Tatiana M. Foroud; Nathan A. Gillespie; Alison M. Goate; David Goldman; Richard A. Grucza; Dana B. Hancock; Kathleen Mullan Harris; Victor Hesselbrock; John K. Hewitt; Christian J. Hopfer; William G. Iacono; Eric O. Johnson; Victor M. Karpyak; Kenneth S. Kendler; Henry R. Kranzler; Kenneth Krauter; Penelope A. Lind; Matt McGue; James MacKillop; Pamela A. F. Madden; Hermine H. Maes; Patrik K. E. Magnusson; Elliot C. Nelson; Markus M. Noethen; Abraham A. Palmer; Brenda W. J. H. Penninx; Bernice Porjesz; John P. Rice; Marcella Rietschel; Brien P. Riley; Richard J. Rose; Pei-Hong Shen; Judy Silberg; Michael C. Stallings; Ralph E. Tarter; Michael M. Vanyukov; Scott Vrieze; Tamara L. Wall; John B. Whitfield; Hongyu Zhao; Benjamin M. Neale; Tracey D. Wade; Andrew C. Heath; Grant W. Montgomery; Nicholas G. Martin; Patrick F. Sullivan; Jaakko Kaprio; Gerome Breen; Joel Gelernter; Howard J. Edenberg; Cynthia M. Bulik; Arpana Agrawal; Institute of Neuroscience and Physiology

doi:10.1111/adb.12880

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Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Journal article

Peer reviewed

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Melissa A. Munn-Chernoff, Emma C. Johnson, Yi-Ling Chou, Jonathan R. I. Coleman, Laura M. Thornton, Raymond K. Walters, Zeynep Yilmaz, Jessica H. Baker, Christopher Hubel, Scott Gordon, …

Addiction biology, Vol.26(1), pp.e12880-n/a

01/2021

DOI: https://doi.org/10.1111/adb.12880

PMCID: 7429266

PMID: 32064741

Abstract

Biochemistry & Molecular Biology

Life Sciences & Biomedicine

Science & Technology

Substance Abuse

Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [r(g)], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from similar to 2400 to similar to 537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (r(g) = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (r(g) = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (r(g) = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (r(gs) = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.

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Title: Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies
Creators - without role: Melissa A. Munn-Chernoff - University of North Carolina at Chapel Hill
Emma C. Johnson - Washington University in St. Louis
Yi-Ling Chou - Washington University in St. Louis
Jonathan R. I. Coleman - King's College London
Laura M. Thornton - University of North Carolina at Chapel Hill
Raymond K. Walters - Massachusetts General Hospital
Zeynep Yilmaz - University of North Carolina at Chapel Hill
Jessica H. Baker - University of North Carolina at Chapel Hill
Christopher Hubel - King's College London
Scott Gordon - QIMR Berghofer Medical Research Institute
Sarah E. Medland - QIMR Berghofer Medical Research Institute
Hunna J. Watson - University of Western Australia
Helena A. Gaspar - King's College London
Julien Bryois - Karolinska Institutet
Anke Hinney - University of Duisburg-Essen
Virpi M. Leppa - Karolinska Institutet
Manuel Mattheisen - Aarhus University
Stephan Ripke - Harvard University
Shuyang Yao - Karolinska Institutet
Paola Giusti-Rodriguez - University of North Carolina at Chapel Hill
Ken B. Hanscombe - King's College London
Roger A. H. Adan - University of Gothenburg
Lars Alfredsson - Karolinska Institutet
Tetsuya Ando - College Station Medical Center
Ole A. Andreassen - Oslo University Hospital
Wade H. Berrettini - University of Pennsylvania
Ilka Boehm - TU Dresden
Claudette Boni - Institute of Psychiatry and Neuroscience of Paris
Vesna Boraska Perica - Wellcome Sanger Institute
Katharina Buehren - RWTH Aachen University
Roland Burghardt - Klinikum Frankfurt Höchst
Matteo Cassina - University of Padua
Sven Cichon - University Hospital of Basel
Maurizio Clementi - University of Padua
Roger D. Cone - University of Michigan–Ann Arbor
Philippe Courtet - University of Montpellier
Scott Crow - University of Minnesota
James J. Crowley - University of North Carolina at Chapel Hill
Unna N. Danner - Altrecht GGZ
Oliver S. P. Davis - MRC Epidemiology Unit
Martina de Zwaan - Medizinische Hochschule Hannover
George Dedoussis - Harokopio University of Athens
Daniela Degortes - University of Padua
Janiece E. DeSocio - Seattle University
Danielle M. Dick - Virginia Commonwealth University
Dimitris Dikeos - Supreme Council Of Health
Christian Dina - Institut du Thorax
Monika Dmitrzak-Weglarz - Poznan University of Medical Sciences
Elisa Docampo - Barcelona Institute for Science and Technology
Laramie E. Duncan - Stanford University
Karin Egberts - Universitätsklinikum Würzburg
Stefan Ehrlich - TU Dresden
Georgia Escaramis - Barcelona Institute for Science and Technology
Tonu Esko - University of Tartu
Xavier Estivill - Centre for Genomic Regulation
Anne Farmer - King's College London
Angela Favaro - University of Padua
Fernando Fernandez-Aranda - Centro de Investigación Biomédica en Red
Manfred M. Fichter - Schön Klinik Roseneck
Krista Fischer - University of Tartu
Manuel Foecker - University of Münster
Lenka Foretova - Masaryk Memorial Cancer Institute
Andreas J. Forstner - University of Bonn
Monica Forzan - University of Padua
Christopher S. Franklin - Wellcome Sanger Institute
Steven Gallinger - University of Toronto
Ina Giegling - Martin Luther University Halle-Wittenberg
Johanna Giuranna - University of Duisburg-Essen
Fragiskos Gonidakis - Eginition Hospital
Philip Gorwood - Institute of Psychiatry and Neuroscience of Paris
Monica Gratacos Mayora - Barcelona Inst Sci & Technol, Barcelona, Spain
Sebastien Guillaume - University of Montpellier
Yiran Guo - Children's Hospital of Philadelphia
Hakon Hakonarson - Children's Hospital of Philadelphia
Konstantinos Hatzikotoulas - Helmholtz Zentrum München
Joanna Hauser - Poznan University of Medical Sciences
Johannes Hebebrand - University of Duisburg-Essen
Sietske G. Helder - King's College London
Stefan Herms - University Hospital of Basel
Beate Herpertz-Dahlmann - RWTH Aachen University
Wolfgang Herzog - University Hospital Heidelberg
Laura M. Huckins - Wellcome Sanger Institute
James I. Hudson - McLean Hospital
Hartmut Imgart - Werner-Wicker-Klinik
Hidetoshi Inoko - Tokai University
Vladimir Janout - Palacký University Olomouc
Susana Jimenez-Murcia - Centro de Investigación Biomédica en Red
Antonio Julia - Vall d'Hebron Institut de Recerca
Gursharan Kalsi - King's College London
Deborah Kaminska - Charles University
Leila Karhunen - University of Eastern Finland
Andreas Karwautz - Medical University of Vienna
Martien J. H. Kas - College Station Medical Center
James L. Kennedy - Centre for Addiction and Mental Health
Anna Keski-Rahkonen - University of Helsinki
Kirsty Kiezebrink - University of Aberdeen
Youl-Ri Kim - Inje University Seoul Paik Hospital
Kelly L. Klump - Michigan State University
Gun Peggy S. Knudsen - Norwegian Institute of Public Health
Maria C. La Via - University of North Carolina at Chapel Hill
Stephanie Le Hellard - University of Bergen
Robert D. Levitan - University of Toronto
Dong Li - Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA
Lisa Lilenfeld - Supreme Council Of Health
Bochao Danae Lin - College Station Medical Center
Jolanta Lissowska - M Sklodowska Curie Canc Ctr, Ctr Oncol, Dept Canc Epidemiol & Prevent, Warsaw, Poland
Jurjen Luykx - College Station Medical Center
Pierre J. Magistretti - King Abdullah Univ Sci & Technol, BESE Div, Thuwal, Saudi Arabia
Mario Maj - University of Campania "Luigi Vanvitelli"
Katrin Mannik - University of Tartu
Sara Marsal - Vall d'Hebron Institut de Recerca
Christian R. Marshall - Sick
Morten Mattingsdal - University of Oslo
Sara McDevitt - Univ Coll Cork, Dept Psychiat, Cork, Cork, Ireland
Peter McGuffin - Kings Coll London, Inst Psychiat Psychol & Neurosci, SGDP Ctr, London, England
Andres Metspalu - University of Tartu
Ingrid Meulenbelt - Leiden University
Nadia Micali - University of Geneva
Karen Mitchell - VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA USA
Alessio Maria Monteleone - University of Campania "Luigi Vanvitelli"
Palmiero Monteleone - University of Salerno
Benedetta Nacmias - University of Florence
Marie Navratilova - Mécanique et Engrenage Moderne
Ioanna Ntalla - Harokopio University of Athens
Julie K. O'Toole - Kartini Clin, Portland, OR USA
Roel A. Ophoff - Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Neurobehav Genet, Los Angeles, CA 90024 USA
Leonid Padyukov - Karolinska Institutet
Aarno Palotie - Massachusetts Institute of Technology
Jacques Pantel - Inserm
Hana Papezova - Charles University
Dalila Pinto - Supreme Council Of Health
Raquel Rabionet - St Joan de Deu Barcelona Childrens Hosp, St Joan de Deu Res Inst, Barcelona, Spain
Anu Raevuori - University of Helsinki
Nicolas Ramoz - Inserm
Ted Reichborn-Kjennerud - Norwegian Inst Publ Hlth, Dept Mental Disorders, Oslo, Norway
Valdo Ricca - University of Florence
Samuli Ripatti - University of Helsinki
Franziska Ritschel - College Station Medical Center
Marion Roberts - Kings Coll London, Inst Psychiat Psychol & Neurosci, SGDP Ctr, London, England
Alessandro Rotondo - University of Pisa
Dan Rujescu - Martin Luther University Halle-Wittenberg
Filip Rybakowski - College Station Medical Center
Paolo Santonastaso - University of Padua
Andre Scherag - College Station Medical Center
Stephen W. Scherer - Sick
Ulrike Schmidt - King's College Hospital
Nicholas J. Schork - JCVI, La Jolla, CA USA
Alexandra Schosser - University of Vienna
Jochen Seitz - Rhein Westfal TH Aachen, Dept Child & Adolescent Psychiat Psychosomat & Ps, Aachen, Germany
Lenka Slachtova - Charles University
P. Eline Slagboom - Leiden University
Margarita C. T. Slof-Op't Landt - Rivierduinen, Ctr Eating Disorders Ursula, Leiden, Netherlands
Agnieszka Slopien - College Station Medical Center
Sandro Sorbi - University of Florence
Beata Swiatkowska - College Station Medical Center
Jin P. Szatkiewicz - Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA
Ioanna Tachmazidou - Wellcome Sanger Institute
Elena Tenconi - University of Padua
Alfonso Tortorella - Univ Naples SUN, Dept Psychiat, Naples, Italy
Federica Tozzi - Stremble Ventures, Brain Sci Dept, Limassol, Cyprus
Janet Treasure - King's College Hospital
Artemis Tsitsika - National and Kapodistrian University of Athens
Marta Tyszkiewicz-Nwafor - College Station Medical Center
Konstantinos Tziouvas - National and Kapodistrian University of Athens
Annemarie A. van Elburg - Altrecht Mental Hlth Inst, Ctr Eating Disorders Rintveld, Zeist, Netherlands
Eric F. van Furth - Rivierduinen, Ctr Eating Disorders Ursula, Leiden, Netherlands
Gudrun Wagner - University of Vienna
Esther Walton - College Station Medical Center
Elisabeth Widen - University of Helsinki
Eleftheria Zeggini - Wellcome Sanger Institute
Stephanie Zerwas - Univ N Carolina, Dept Psychiat, 101 Manning Dr,Campus Box 7160, Chapel Hill, NC 27515 USA
Stephan Zipfel - College Station Medical Center
Andrew W. Bergen - BioRealm
Joseph M. Boden - University of Otago
Harry Brandt - Sheppard and Enoch Pratt Hospital
Steven Crawford - Sheppard and Enoch Pratt Hospital
Katherine A. Halmi - College Station Medical Center
L. John Horwood - University of Otago
Craig Johnson - Eating Recovery Ctr, Denver, CO USA
Allan S. Kaplan - Ctr Addict & Mental Hlth, Toronto, ON, Canada
Walter H. Kaye - Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
James Mitchell - University of North Dakota
Catherine M. Olsen - College Station Medical Center
John F. Pearson - University of Otago
Nancy L. Pedersen - Karolinska Institutet
Michael Strober - Univ Calif Los Angeles, Dept Psychiat & Behav Sci, Semel Inst Neurosci & Human Behav, Los Angeles, CA USA
Thomas Werge - University of Copenhagen
David C. Whiteman - College Station Medical Center
D. Blake Woodside - University of Toronto
Jakob Grove - Aarhus University
Anjali K. Henders - University of Queensland
Janne T. Larsen - Lundbeck
Richard Parker - College Station Medical Center
Liselotte V. Petersen - Lundbeck
Jennifer Jordan - University of Otago
Martin A. Kennedy - University of Otago
Andreas Birgegard - Karolinska Institutet
Paul Lichtenstein - Karolinska Institutet
Claes Norring - Karolinska Institutet
Mikael Landen - Karolinska Institutet
Preben Bo Mortensen - Lundbeck
Renato Polimanti - Supreme Council Of Health
Jeanette N. McClintick - Indiana University
Amy E. Adkins - Virginia Commonwealth University
Fazil Aliev - Virginia Commonwealth University
Silviu-Alin Bacanu - Virginia Commonwealth University
Anthony Batzler - Mayo Clin, Psychiat Genom & Pharmacogen Program, Rochester, MN USA
Sarah Bertelsen - Supreme Council Of Health
Joanna M. Biernacka - Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Tim B. Bigdeli - State Univ New York Downstate Med Ctr, Dept Psychiat & Behav Sci, Brooklyn, NY USA
Li-Shiun Chen - Supreme Council Of Health
Toni-Kim Clarke - University of Edinburgh
Franziska Degenhardt - University of Bonn
Anna R. Docherty - University of Utah
Alexis C. Edwards - Virginia Commonwealth University
Jerome C. Foo - Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet Epidmiol Psychiat, Mannheim, Germany
Louis Fox - Supreme Council Of Health
Josef Frank - Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet Epidmiol Psychiat, Mannheim, Germany
Laura M. Hack - Stanford University
Annette M. Hartmann - Martin Luther University Halle-Wittenberg
Sarah M. Hartz - Supreme Council Of Health
Stefanie Heilmann-Heimbach - University of Bonn
Colin Hodgkinson - NIAAA, Lab Neurogenet, NIH, Bethesda, MD USA
Per Hoffmann - University of Bonn
Jouke-Jan Hottenga - University of Amsterdam
Bettina Konte - Martin Luther University Halle-Wittenberg
Jari Lahti - University of Turku
Marius Lahti-Pulkkinen - University of Helsinki
Dongbing Lai - Indiana University
Lannie Ligthart - University of Amsterdam
Anu Loukola - University of Helsinki
Brion S. Maher - Supreme Council Of Health
Hamdi Mbarek - University of Amsterdam
Andrew M. McIntosh - University of Edinburgh
Matthew B. McQueen - Univ Colorado, Dept Integrat Physiol, Boulder, CO 80309 USA
Jacquelyn L. Meyers - College Station Medical Center
Yuri Milaneschi - University of Amsterdam
Teemu Palviainen - University of Helsinki
Roseann E. Peterson - Virginia Commonwealth University
Euijung Ryu - Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA
Nancy L. Saccone - Harvard University
Jessica E. Salvatore - Virginia Commonwealth University
Sandra Sanchez-Roige - Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
Melanie Schwandt - Boston University
Richard Sherva - Harvard University
Fabian Streit - Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet Epidmiol Psychiat, Mannheim, Germany
Jana Strohmaier - Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet Epidmiol Psychiat, Mannheim, Germany
Nathaniel Thomas - Virginia Commonwealth University
Jen-Chyong Wang - Supreme Council Of Health
Bradley T. Webb - Virginia Commonwealth University
Robbee Wedow - College Station Medical Center
Leah Wetherill - Indiana University
Amanda G. Wills - Univ Colorado, Inst Behav Sci, Boulder, CO 80309 USA
Hang Zhou - Supreme Council Of Health
Jason D. Boardman - Univ Colorado, Dept Sociol, Boulder, CO 80309 USA
Danfeng Chen - Massachusetts Institute of Technology
Doo-Sup Choi - University of Vermont
William E. Copeland - Washington Univ, Sch Med, Dept Med, Div Biostat, St Louis, MO 63110 USA
Robert C. Culverhouse - Johannes Gutenberg Univ Mainz, Dept Psychiat, Mainz, Germany
Norbert Dahmen - UNSW Sydney
Louisa Degenhardt - Stanford University
Benjamin W. Domingue - Univ Dusseldorf, Dept Psychiat & Psychotherapy, Dusseldorf, Germany
Mark A. Frye - Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA
Wolfgang Gabel - University of Edinburgh
Caroline Hayward - Max
Marcus Ising - University of Minnesota
Margaret Keyes - Heidelberg Univ, Med Fac Mannheim, Dept Addict Behav & Addict Med, Cent Inst Mental Hlth, Mannheim, Germany
Falk Kiefer - Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany
Gabriele Koller - University of Iowa
John Kramer - Kings Coll London, Inst Psychiat Psychol & Neurosci, Addict Dept, London, England
Samuel Kuperman - University of Bonn
Susanne Lucae - University of Minnesota
Michael T. Lynskey - University of Bonn
Wolfgang Maier - Natl Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland
Karl Mann - Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany
Satu Maennistoe - Max
Bertram Mueller-Myhsok - University of Aberdeen
Alison D. Murray - Indiana University
John I. Nurnberger - Supreme Council Of Health
Ulrich Preuss - Vitos
Katri Raikkonen - University of Helsinki
Maureen D. Reynolds - University of Regensburg
Monika Ridinger - University of Duisburg-Essen
Norbert Scherbaum - College Station Medical Center
Marc A. Schuckit - Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
Michael Soyka - Ludwig Maximilians Univ Munchen, Psychiat Hosp, Bernau, Germany
Jens Treutlein - Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet Epidmiol Psychiat, Mannheim, Germany
Stephanie H. Witt - Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet Epidmiol Psychiat, Mannheim, Germany
Norbert Wodarz - Ludwig Maximilians Univ Munchen, Hosp Psychiat, Dept Psychiat, Munich, Germany
Peter Zill - University of Utah
Daniel E. Adkins - University of Utah
Dorret I. Boomsma - University of Amsterdam
Laura J. Bierut - Supreme Council Of Health
Sandra A. Brown - Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
Kathleen K. Bucholz - Supreme Council Of Health
E. Jane Costello - University of Chicago
Harriet De Wit - NIAAA, Intramural Res Program, Bethesda, MD USA
Nancy Diazgranados - University of Helsinki
Johan G. Eriksson - Natl Inst Hlth & Welf, Helsinki, Finland
Lindsay A. Farrer - Harvard University
Tatiana M. Foroud - Indiana University
Nathan A. Gillespie - Virginia Commonwealth University
Alison M. Goate - Supreme Council Of Health
David Goldman - NIAAA, Lab Neurogenet, NIH, Bethesda, MD USA
Richard A. Grucza - Supreme Council Of Health
Dana B. Hancock - Univ N Carolina, Dept Sociol, Chapel Hill, NC 27515 USA
Kathleen Mullan Harris - Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC 27515 USA
Victor Hesselbrock - Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA
John K. Hewitt - Univ Colorado, Dept Psychiat, Aurora, CO USA
Christian J. Hopfer - RTI
William G. Iacono - Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany
Eric O. Johnson - Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC 27515 USA
Victor M. Karpyak - Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Kenneth S. Kendler - Virginia Commonwealth University
Henry R. Kranzler - VA Healthcare-VISN 4
Kenneth Krauter - McMaster University
Penelope A. Lind - College Station Medical Center
Matt McGue - Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany
James MacKillop - McMaster University
Pamela A. F. Madden - Supreme Council Of Health
Hermine H. Maes - Virginia Commonwealth University
Patrik K. E. Magnusson - Karolinska Institutet
Elliot C. Nelson - Supreme Council Of Health
Markus M. Noethen - University of Bonn
Abraham A. Palmer - Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
Brenda W. J. H. Penninx - Indiana University Bloomington
Bernice Porjesz - College Station Medical Center
John P. Rice - Supreme Council Of Health
Marcella Rietschel - Heidelberg University
Brien P. Riley - Virginia Commonwealth University
Richard J. Rose - Yale University
Pei-Hong Shen - NIAAA, Lab Neurogenet, NIH, Bethesda, MD USA
Judy Silberg - Virginia Commonwealth University
Michael C. Stallings - RTI Int, Fellow Program, Res Triangle Pk, NC USA
Ralph E. Tarter - University of Duisburg-Essen
Michael M. Vanyukov - University of Duisburg-Essen
Scott Vrieze - Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany
Tamara L. Wall - Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
John B. Whitfield - College Station Medical Center
Hongyu Zhao - Flinders University
Benjamin M. Neale - College Station Medical Center
Tracey D. Wade - University of Queensland
Andrew C. Heath - Supreme Council Of Health
Grant W. Montgomery - College Station Medical Center
Nicholas G. Martin - College Station Medical Center
Patrick F. Sullivan - Univ N Carolina, Dept Psychiat, 101 Manning Dr,Campus Box 7160, Chapel Hill, NC 27515 USA
Jaakko Kaprio - University of Helsinki
Gerome Breen - Kings Coll London, Inst Psychiat Psychol & Neurosci, SGDP Ctr, London, England
Joel Gelernter - Supreme Council Of Health
Howard J. Edenberg - Indiana University
Cynthia M. Bulik - Univ N Carolina, Dept Psychiat, 101 Manning Dr,Campus Box 7160, Chapel Hill, NC 27515 USA
Arpana Agrawal - Supreme Council Of Health
Institute of Neuroscience and Physiology
Publication Details: Addiction biology, Vol.26(1), pp.e12880-n/a
Publisher: Wiley
Number of pages: 20
Grant note: UL1 TR001863 / NCATS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) Wellcome Trust; European Commission R01 GM126479 / NIGMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) R01 AA013320; T32 AA007464; R37 AA011408; K02 AA018755; R01 AA013321; K01 AA024152; R01 AA012502; R37 AA009367; P50 AA022537; P20 AA017830; R37 AA007728; R01 AA011408; R01 AA015416; U01 AA027487; F32 AA027435; R21 AA022717; P50 AA011998; R21 AA024888; R21 AA025214; R01 AA017444; K01 AA025113 / NIAAA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) U01 MH109528; R01 MH100549; R01 MH092793; K01 MH109782; K01 MH109765; R01 MH066140; K01 MH113848; U01 MH109514; U01 MH109532; R01 MH123619; R01 MH124871; K01 MH093731; U01 MH094432; U01 MH109539; K01 MH106675 / NIMH NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) MC_UU_00007/10 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) R01 HG008983 / NHGRI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) R01 DA002812; R01 DA030005; R01 DA013240; R01 DA024417; R01 DA012854; R01 DA036583; P30 DA023026; R01 DA012690; R01 DA021905; R01 DA011301; R01 DA024413; R01 DA037558; R01 DA038076; K01 DA037914; R21 DA040177; R01 DA025109; R00 DA023549; R01 DA032015; R01 DA005147; R01 DA016977; R01 DA036216; K24 DA032555; R01 DA042090; P60 DA011015; K02 DA032573; P50 DA037844; R01 DA036523; R01 DA035804; R01 DA037904 / NIDA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) MC_UU_00007/10 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission R01 HD073342; R01 HD060726; P01 HD031921; R01 HD093651; P2C HD050924; R03 HD097630; P2C HD066613 / NICHD NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Identifiers: 9945730608331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article