Abstract
A metal‐free, mild, eco‐friendly and efficient method has been developed for the synthesis of functionalized tetrahydroquinolines, quinazolin‐4(1H)‐ones and quinazolin‐4(3H)‐ones using metal‐free and economically viable heterogeneous catalyst PPA‐SiO2 in water preferentially forming cis‐isomer. Both electron withdrawing and electron donating groups were found to be well tolerated and isolated products were obtained in good yields. Cis‐isomer was predominant in case of electron donating substrate in water.
Heterogeneous catalyst PPA‐SiO2 catalyzed metal‐free, mild, eco‐friendly and efficient method has been developed for the synthesis of functionalized tetrahydroquinolines, quinazolin‐4(1H)‐ones and quinazolin‐4(3H)‐ones derivatives in water. Preferentially cis‐ tetrahydroquinolines were formed in a short reaction time.