Abstract
A reversed-phase high-performance liquid chromatographic method for the simultaneous determination of furazolidone and ifuroxime in vaginal suppositories is described. A lichrosorb R.P. 18 (4 × 250 mm) 5 μm column and a mobile phase consisting of methanol-water-buffer pH 3 (40 : 55 : 5) were used. Calibration graphs were rectilinear over the concentration range 1-10 μ/ml for both drugs. Separation was achieved in 12 min. at a wavelength of 350 nm. The proposed method was applied to suppositories containing. the two species, and the results obtained were accurate and precise.