Single-Nucleotide Polymorphisms in Rv2629 Are Specific for Mycobacterium tuberculosis Genotypes Beijing and Ghana but Not Associated with Rifampin Resistance

Susanne Homolka; Claudio Köser; John Archer; Sabine Rüsch-Gerdes; Stefan Niemann

doi:10.1128/JCM.01237-08

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Single-Nucleotide Polymorphisms in Rv2629 Are Specific for Mycobacterium tuberculosis Genotypes Beijing and Ghana but Not Associated with Rifampin Resistance

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Single-Nucleotide Polymorphisms in Rv2629 Are Specific for Mycobacterium tuberculosis Genotypes Beijing and Ghana but Not Associated with Rifampin Resistance

Susanne Homolka, Claudio Köser, John Archer, Sabine Rüsch-Gerdes and Stefan Niemann

Journal of clinical microbiology, Vol.47(1), pp.223-226

01/01/2009

DOI: https://doi.org/10.1128/JCM.01237-08

PMCID: PMC2620844

PMID: 19020060

Abstract

Mycobacteriology and Aerobic Actinomycetes

Sequence analysis of 58 multidrug-resistant Mycobacterium tuberculosis complex strains from Germany and 55 susceptible strains from a reference collection comprising major phylogenetic lineages confirmed that variations in Rv2629, 191A/C and 965C/T, are specific for genotypes Beijing and Ghana, respectively, but not involved in the development of rifampin (rifampicin) resistance.

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Title: Single-Nucleotide Polymorphisms in Rv2629 Are Specific for Mycobacterium tuberculosis Genotypes Beijing and Ghana but Not Associated with Rifampin Resistance
Creators - without role: Susanne Homolka - Research Center Borstel - Leibniz Lung Center
Claudio Köser - University of Cambridge
John Archer - University of Cambridge
Sabine Rüsch-Gerdes - Research Center Borstel - Leibniz Lung Center
Stefan Niemann - Research Center Borstel - Leibniz Lung Center
Publication Details: Journal of clinical microbiology, Vol.47(1), pp.223-226
Publisher: American Society for Microbiology (ASM)
Identifiers: 9945845208331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article