Abstract
The organic extract of the soft coral
Sinularia gibberosa, collected from the northern Taiwan, has been investigated and resulted in the isolation of five new xeniaphyllane-type diterpenoids with a rare cyclic peroxyhemiketal (3,6-dihydro-1,2-dioxin-3-ol) moiety, sinugibberosides A–E (
1–
5). The structures of the new terpenoids, including their stereochemistries, were established on the basis of extensive spectroscopic analysis, including 1D and 2D NMR (
1H–
1H COSY, HMQC, HMBC, and NOESY), and by comparison of their NMR data with those of related compounds. Metabolites
1–
5 represent the first example of marine terpenoids possessing a cyclic peroxyhemiketal moiety.
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