Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT)

M Mohty; F Malard; M Abecassis; E Aerts; A S Alaskar; M Aljurf; M Arat; P Bader; F Baron; A Bazarbachi; D Blaise; F Ciceri; S Corbacioglu; J-H Dalle; R F Duarte; T Fukuda; A Huynh; T Masszi; M Michallet; A Nagler; M NiChonghaile; T Pagluica; C Peters; F B Petersen; P G Richardson; T Ruutu; B N Savani; E Wallhult; I Yakoub-Agha; E Carreras

doi:10.1038/bmt.2015.52

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Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT)

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Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT)

M Mohty, F Malard, M Abecassis, E Aerts, A S Alaskar, M Aljurf, M Arat, P Bader, F Baron, A Bazarbachi, …

Bone marrow transplantation (Basingstoke), Vol.50(6), pp.781-789

01/06/2015

DOI: https://doi.org/10.1038/bmt.2015.52

PMCID: PMC4456788

PMID: 25798682

Abstract

Adult

Biomarkers - blood

Hematopoietic Stem Cell Transplantation - adverse effects

Humans

Postoperative Complications - blood

Postoperative Complications - diagnosis

Postoperative Complications - physiopathology

Postoperative Complications - therapy

Risk Factors

Vascular Diseases - blood

Vascular Diseases - diagnosis

Vascular Diseases - etiology

Vascular Diseases - physiopathology

Vascular Diseases - therapy

Sinusoidal obstruction syndrome or veno-occlusive disease (SOS/VOD) is a potentially life-threatening complication of hematopoietic SCT (HSCT). This review aims to highlight, on behalf of the European Society for Blood and Marrow Transplantation, the current knowledge on SOS/VOD pathophysiology, risk factors, diagnosis and treatments. Our perspectives on SOS/VOD are (i) to accurately identify its risk factors; (ii) to define new criteria for its diagnosis; (iii) to search for SOS/VOD biomarkers and (iv) to propose prospective studies evaluating SOS/VOD prevention and treatment in adults and children.

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Title: Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT)
Creators - without role: M Mohty - Hôpital Saint-Antoine
F Malard - Hôpital Saint-Antoine
M Abecassis - Inst Portugues Oncologia, Lisboa, Portugal
E Aerts - University Hospital of Zurich
A S Alaskar - King Abdullah International Medical Research Center
M Aljurf - King Faisal Specialist Hospital & Research Centre
M Arat - Istanbul Florence Nightingale Hospital
P Bader - Goethe University Frankfurt
F Baron - University of Liège
A Bazarbachi - American University of Beirut
D Blaise - Institute Paoli-Calmettes
F Ciceri - Vita-Salute San Raffaele University
S Corbacioglu - University of Regensburg
J-H Dalle - Délégation Paris 7
R F Duarte - Institut Català d'Oncologia
T Fukuda - HSCT division, National Cancer Center Hospital, Tokyo, Japan
A Huynh - University Cancer Institute Toulouse Oncopole
T Masszi - Unified Szent István and Szent László Hospital
M Michallet - Hôpital Lyon Sud
A Nagler - Sheba Medical Center
M NiChonghaile - Trinity College Dublin
T Pagluica - King's College Hospital
C Peters - St Anna Children's Hospital
F B Petersen - LDS Hospital
P G Richardson - Dana-Farber Cancer Institute
T Ruutu - Helsinki University Hospital
B N Savani - Vanderbilt University Medical Center
E Wallhult - Sahlgrenska University Hospital
I Yakoub-Agha - Centre Hospitalier Universitaire de Lille
E Carreras - Josep Carreras Leukaemia Research Institute
Publication Details: Bone marrow transplantation (Basingstoke), Vol.50(6), pp.781-789
Identifiers: 9921885608331
Academic Unit: King Saud Bin Abdulaziz University for Health Sciences
Language: English
Resource Type: Journal article