Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Maria Soler Artigas; Louise V. Wain; Suzanne Miller; Abdul Kader Kheirallah; Jennifer E. Huffman; Ioanna Ntalla; Nick Shrine; Ma'en Obeidat; Holly Trochet; Wendy L. McArdle; Alexessander Couto Alves; Jennie Hui; Jing Hua Zhao; Peter K. Joshi; Alexander Teumer; Eva Albrecht; Medea Imboden; Rajesh Rawal; Lorna M. Lopez; Jonathan Marten; Stefan Enroth; Ida Surakka; Ozren Polasek; Leo-Pekka Lyytikainen; Raquel Granell; Pirro G. Hysi; Claudia Flexeder; Anubha Mahajan; John Beilby; Yohan Bosse; Corry-Anke Brandsma; Harry Campbell; Christian Gieger; Sven Glaeser; Juan R. Gonzalez; Harald Grallert; Chris J. Hammond; Sarah E. Harris; Anna-Liisa Hartikainen; Markku Heliovaara; John Henderson; Lynne Hocking; Momoko Horikoshi; Nina Hutri-Kahonen; Erik Ingelsson; Asa Johansson; John P. Kemp; Ivana Kolcic; Ashish Kumar; Lars Lind; Erik Melen; Arthur W. Musk; Pau Navarro; David C. Nickle; Sandosh Padmanabhan; Olli T. Raitakari; Janina S. Ried; Samuli Ripatti; Holger Schulz; Robert A. Scott; Don D. Sin; John M. Starr; Ana Vinuela; Henry Voelzke; Sarah H. Wild; Alan F. Wright; Tatijana Zemunik; Deborah L. Jarvis; Tim D. Spector; David M. Evans; Terho Lehtimaki; Veronique Vitart; Mika Kahonen; Ulf Gyllensten; Igor Rudan; Ian J. Deary; Stefan Karrasch; Nicole M. Probst-Hensch; Joachim Heinrich; Beate Stubbe; James F. Wilson; Nicholas J. Wareham; Alan L. James; Andrew P. Morris; Marjo-Riitta Jarvelin; Caroline Hayward; Ian Sayers; David P. Strachan; Ian P. Hall; Martin D. Tobin; Panos Deloukas; Anna L. Hansell; Richard Hubbard; Victoria E. Jackson; Jonathan Marchini; Ian Pavord; Neil C. Thomson; Eleftheria Zeggini; UK BiLEVE

doi:10.1038/ncomms9658

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Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

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Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Maria Soler Artigas, Louise V. Wain, Suzanne Miller, Abdul Kader Kheirallah, Jennifer E. Huffman, Ioanna Ntalla, Nick Shrine, Ma'en Obeidat, Holly Trochet, Wendy L. McArdle, …

Nature communications, Vol.6(1), pp.8658-8658

04/12/2015

DOI: https://doi.org/10.1038/ncomms9658

PMCID: PMC4686825

PMID: 26635082

Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P < 5 x 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

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Title: Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Creators - without role: Maria Soler Artigas - University of Leicester
Louise V. Wain - University of Leicester
Suzanne Miller - University of Nottingham
Abdul Kader Kheirallah - University of Nottingham
Jennifer E. Huffman - University of Edinburgh
Ioanna Ntalla - University of Leicester
Nick Shrine - University of Leicester
Ma'en Obeidat - University of British Columbia
Holly Trochet - University of Edinburgh
Wendy L. McArdle - University of Bristol
Alexessander Couto Alves - University of London
Jennie Hui - College Station Medical Center
Jing Hua Zhao - University of Cambridge
Peter K. Joshi - University of Edinburgh
Alexander Teumer - College Station Medical Center
Eva Albrecht - Helmholtz Zentrum München
Medea Imboden - Swiss Trop & Publ Hlth Inst, CH-4051 Basel, Switzerland
Rajesh Rawal - Helmholtz Zentrum München
Lorna M. Lopez - University of Edinburgh
Jonathan Marten - University of Edinburgh
Stefan Enroth - Uppsala University
Ida Surakka - University of Helsinki
Ozren Polasek - University of Edinburgh
Leo-Pekka Lyytikainen - Fimlab
Raquel Granell - University of Bristol
Pirro G. Hysi - Kings Coll London, KCL Dept Twins Res & Genet Epidemiol, London WC2R 2LS, England
Claudia Flexeder - Helmholtz Zentrum München
Anubha Mahajan - University of Oxford
John Beilby - College Station Medical Center
Yohan Bosse - MED Institute
Corry-Anke Brandsma - University of Groningen
Harry Campbell - University of Edinburgh
Christian Gieger - Helmholtz Zentrum München
Sven Glaeser - Intens
Juan R. Gonzalez - Ctr Res Environm Epidemiol CREAL, E-08003 Barcelona, Spain
Harald Grallert - Helmholtz Zentrum München
Chris J. Hammond - Kings Coll London, KCL Dept Twins Res & Genet Epidemiol, London WC2R 2LS, England
Sarah E. Harris - University of Edinburgh
Anna-Liisa Hartikainen - Massachusetts Rehabilitation Commission
Markku Heliovaara - Natl Inst Hlth & Welf THL, FI-00271 Helsinki, Finland
John Henderson - University of Bristol
Lynne Hocking - Generat Scotland, Aberdeen, Scotland
Momoko Horikoshi - University of Oxford
Nina Hutri-Kahonen - Tampere University
Erik Ingelsson - University of Oxford
Asa Johansson - Uppsala University
John P. Kemp - University of Bristol
Ivana Kolcic - University of Split
Ashish Kumar - Swiss Trop & Publ Hlth Inst, CH-4051 Basel, Switzerland
Lars Lind - Uppsala University
Erik Melen - Karolinska Institutet
Arthur W. Musk - College Station Medical Center
Pau Navarro - University of Edinburgh
David C. Nickle - Merck Res Labs, Genet & Pharmacogen, Boston, MA 02115 USA
Sandosh Padmanabhan - Generat Scotland, Aberdeen, Scotland
Olli T. Raitakari - College Station Medical Center
Janina S. Ried - Helmholtz Zentrum München
Samuli Ripatti - University of Helsinki
Holger Schulz - Helmholtz Zentrum München
Robert A. Scott - University of Cambridge
Don D. Sin - University of British Columbia
John M. Starr - University of Edinburgh
Ana Vinuela - Kings Coll London, KCL Dept Twins Res & Genet Epidemiol, London WC2R 2LS, England
Henry Voelzke - College Station Medical Center
Sarah H. Wild - University of Edinburgh
Alan F. Wright - University of Edinburgh
Tatijana Zemunik - University of Split
Deborah L. Jarvis - University of London
Tim D. Spector - Kings Coll London, KCL Dept Twins Res & Genet Epidemiol, London WC2R 2LS, England
David M. Evans - University of Bristol
Terho Lehtimaki - Fimlab
Veronique Vitart - University of Edinburgh
Mika Kahonen - University of Tampere
Ulf Gyllensten - Uppsala University
Igor Rudan - University of Edinburgh
Ian J. Deary - University of Edinburgh
Stefan Karrasch - Helmholtz Zentrum München
Nicole M. Probst-Hensch - Swiss Trop & Publ Hlth Inst, CH-4051 Basel, Switzerland
Joachim Heinrich - Helmholtz Zentrum München
Beate Stubbe - Intens
James F. Wilson - University of Edinburgh
Nicholas J. Wareham - University of Cambridge
Alan L. James - College Station Medical Center
Andrew P. Morris - University of Oxford
Marjo-Riitta Jarvelin - University of London
Caroline Hayward - Generat Scotland, Aberdeen, Scotland
Ian Sayers - University of Nottingham
David P. Strachan - University of London
Ian P. Hall - University of Nottingham
Martin D. Tobin - University of Leicester
Panos Deloukas - Queen Mary University of London
Anna L. Hansell - University of London
Richard Hubbard - University of Nottingham
Victoria E. Jackson - University of Leicester
Jonathan Marchini - University of Oxford
Ian Pavord - University of Oxford
Neil C. Thomson - University of Glasgow
Eleftheria Zeggini - Wellcome Sanger Institute
UK BiLEVE
Publication Details: Nature communications, Vol.6(1), pp.8658-8658
Publisher: NATURE PORTFOLIO
Number of pages: 12
Grant note: 5R01MH63706:02 / NIH/NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) FKZ 01GI0882 / subnetwork COSYCONET Department of Health Canton Lung League of Graubunden NIH Center for Inherited Disease Research; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA British Heart Foundation Helmholtz Zentrum Munchen-German Research Center for Environmental Health - German Federal Ministry of Education and Research Competence Network ASCONET X51001 / Tampere University Hospital Medical Funds Abbott Diagnostics; Abbott Laboratories SUVA Pfizer MC_PC_U127592696; 1201677; G0501942; MC_PC_13048; MC_PC_U127561128; G0902313; MC_UU_12015/1; G0600705; MR/K026992/1; G1002319; MC_UU_12013/4; G1001799; G1000861; MR/L01341X/1; MC_U106179471; MR/N01104X/1; MC_PC_12010; G0000934 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) German Asthma Medical Research Fund of the Tampere University Hospital 018996; LSHG-CT-2006-01947 / European Commission; European Union (EU); European Commission Joint Research Centre SRF/01/010; NF-SI-0512-10135 / National Institute for Health Research; National Institutes of Health Research (NIHR) French Ministry of Research; Ministry of Research, France Federal Office for the Environment G1000861 / MRC programme; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Stiftung ehemals Bundner Heilstatten 1RO1EY018246 / US National Institutes of Health/National Eye Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) 251217; 255847; NFBC1966; 104781; 120315; 129269; 1114194; 24300796 / Academy of Finland; Research Council of Finland East Midlands Development Agency BB/F019394/1 / UK's Biotechnology and Biological Sciences Research Council (BBSRC); UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) University Hospital Oulu European Community National Institute of Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) Healthcare and Bioscience iNet European Union; European Union (EU) Munich Center of Health Sciences (MC Health) Uppsala University 617306 / ERC Consolidator Grant; European Research Council (ERC) Social Ministry of the Federal State of Mecklenburg-West Pomerania ETM/55; CZB/4/710; CZD/16/6/4; CZB/4/505 / Chief Scientist Office ICA08-0047 / Swedish Foundation for Strategic Research; Swedish Foundation for Humanities & Social Sciences LSHG-CT-2006-018947 / European Union; European Union (EU) Swiss Lung League Busselton Health Study (BHS) Foundation for Strategic Research (SSF); Swedish Foundation for Strategic Research Federal Office of Public Health King's College London Canton Government of Basel-Stadt Canton Lung League of Ticino NIHR; National Institutes of Health Research (NIHR) 2012-1397 / Swedish Research Council Ministry of Cultural Affairs BBSRC; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) HEALTH-F4-2007-201413; 277849 / EU; European Union (EU) Stroke Association Canton Government of Aargau Canton Lung League of Valais MRC Human Genetics Unit; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Great Wine Estates of the Margaret River region of Western Australia Talecris Biotherapeutics GmbH Clinical Research Facility and Biomedical Research Centre 01ZZ9603; 01ZZ0103; 01ZZ0403; 03IS2061A; BMBF 01GI0883 / COPD Network (COSYCONET) Canton Government of Luzern G0000934 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 201413; 261433 / Center of Excellence in Complex Disease Genetics, EU 079895 / Wellcome Trust Strategic Award; Wellcome Trust 20120197 / Swedish Heart-Lung Foundation UK Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) QLK4-CT-1999-01237 / ECRHS II Canton Lung League of Geneva 33CS30-148470/1; 33CSCO-134276/1; 33CSCO-108796; 3247BO-104283; 3247BO-104288; 3247BO-104284; 3247-065896; 3100-059302; 3200-052720; 3200-042532; 4026-028099; PMPDP3_129021/1; PMPDP3_141671/1 / Swiss National Science Foundation; Swiss National Science Foundation (SNSF) National Institute for Health Research (NIHR); National Institutes of Health Research (NIHR) Sigrid Juselius Foundation 018996 / EU (GABRIEL); European Union (EU) MC_PC_U127561128; G0902313; MC_PC_U127592696; G0600705; MR/N01104X/1; G0000934; G1002319; MR/L01341X/1; MC_PC_12010; MC_UU_12013/4; G1001799; G0501942; MC_UU_12015/1; G1000861 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Food Standards Agency Fonds de recherche Quebec Sante (FRQS) State of Bavaria Canton's Lung League of Basel-Stadt/Basel Landschaft G0902313 / Medical Research Council Senior Clinical Fellowship; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Freiwillige Akademische Gesellschaft Ludwig-Maximilians-Universitat as part of LMUinnovativ Canton Lung League of Zurich 068545/Z/02; 076113/B/04/Z; WT 084703MA; 092731; WT098017; WT064890; WT090532 / Wellcome Trust Biocenter 75617 / University of Oulu, Finland Juvenile Diabetes Research Foundation International; Juvenile Diabetes Research Foundation 216-1080315-0302 / Ministry of Science, Education and Sport in the Republic of Croatia; Ministry of Science, Education and Sports, Republic of Croatia National Human Genome Research Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) G0902313; G0501942 / MRC fellowships; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Canton Government of Valais 03ZIK012 / Federal State of Mecklenburg-West Pomerania National Institute for Health Research Cambridge Biomedical Research Centre; National Institutes of Health Research (NIHR) Royal Society Chief Scientist Office of the Scottish Government Canton Government of Zurich BB/F019394/1 / Biotechnology and Biological Sciences Research Council; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) Swedish Society of Medicine Federal Office of Roads and Transport p2013056 / SNIC through Uppsala Multidisciplinary Center for Advanced Computational Science (UPPMAX) network 'Greifswald Approach to Individualized Medicine (GANI_MED)' - Federal Ministry of Education and Research Finnish Foundation for Cardiovascular Research Medical Research Council UK; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Canton Government of Geneva K2007-66X-20270-01-3; 2012-2884 / Swedish Medical Research Council; Swedish Medical Research Council (SMRC) European Regional Development Fund; European Union (EU) 8875 / Croatian Science Foundation G1000861 / Medical Research Council programme; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 5R01HL087679-02; 1RL1MH083268-01 / NHLBI through the STAMPEED program BMBF FKZ 01ET0713; 01ET1003A / German Federal Ministry of Education and Research; Federal Ministry of Education & Research (BMBF) Biocentrum Helsinki Canton Government of Ticino Canton Government of Basel-Land BB/F019394/1 / BBSRC; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) Siemens Healthcare, Erlangen, Germany; Siemens AG Merck Research Laboratories; Merck & Company (MC_PC_12010) / Medical Research Council (MRC); UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Cancer Research UK CZD/16/6 / Chief Scientist Office National Institute of Allergy and Infectious Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) G0500539; G1002319; G0600705 / Medical Research Council, UK; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Scottish Executive Health Department UBS Wealth Foundation Federal Ministry of Education and Research; Federal Ministry of Education & Research (BMBF)
Identifiers: 9940212708331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article