Abstract
THREE analogs of Bradykinin, (Cys(6,8)) BK, (Cys(2,5)) BK and (Cys(1,9)) BK were synthesized by modified solid phase peptide synthesis with the application of microwave energy. The effect of the replacement of; Ser(6) and Phe(8) by Cys(6,8), Pro(2) and Phe(5) by Cys(2,5), and Arg(1,9) by Cys(1,9) on the biological activity of bradykinin was investigated. A continued work of a previously done study includes synthesis of three BK analogs, (Lys(1)) BK, (Lys(9)) BK and (Lys(1, 9)) BK, using the modified solid phase peptide synthesis with microwave energy. The six analogues have been tested in vitro for their effect on heart rate and in isolated organ for the arterial pressure of rats.