Abstract
This research work aims to measure the solubility and solvation behavior of a novel anticancer compound N′-(1-(N-(methyl) benzylaminomethyl)-2-oxoindolin-3-ylidene)-2-(benzyloxy) benzohydrazide (coded as S20) in various [polyethylene glycol 400 (PEG 400)+water) mixtures]. The solubilities expressed as mole fraction of S20 were measured at five different temperatures (i.e. T=298.15K to 318.15K) and atmospheric pressure. The solubility expressed as mole fraction of S20 was observed maximum in neat PEG 400 (1.13×10−2 at T=318.15K) and minimum in neat water (1.07×10−6 at T=298.15K). The process of dissolution of S20 was found to be an endothermic, spontaneous and entropy driven in all (PEG 400+water) mixtures including neat solvents. Enthalpy-entropy compensation analysis indicated that the driven mechanism for solvation behavior of S20 was enthalpy driven in all cosolvent mixtures.