Abstract
The solubility of apremilast (APM) in different "Transcutole + water" cosolvent mixtures was determined and correlated at "T = 298.2 K-318.2 K" and 'p = 0.1 MPa'. The experimental solubilities of APM were determined and correlated with "Apelblat, van't Hoff, Yalkowsky and Jouyban-Acree equations". The maximum solubilities of APM in mole fraction were obtained in neat Transcutol (2.53 x 10(-2) at T = 318.2 K). Based on activity coefficients, strong molecular interactions were obtained between APM and neat Transcutol in comparison with APM and neat water. "Apparent thermodynamic analysis" showed an "endothermic and entropy-driven dissolution" of APM. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.