Abstract
The solubilities of crystalline vanillin were measured in various Carbitol-water mixtures at different temperatures and atmospheric pressure by an isothermal method. The measured solubilities were compared with calculated ones. The root mean square deviations in the range of 0.18-5.62 % showed good correlation between experimental and calculated solubilities of vanillin. The mole fraction solubility of vanillin was found to be highest in pure Carbitol (2.37 x 10(-1) at 298.15 K) and lowest in pure water (1.23 x 10(-3) at 298.15 K) at each temperature investigated. The solubility data of vanillin was also treated thermodynamically and results indicated an endothermic, spontaneous and an entropy-driven dissolution of vanillin in all Carbitol-water mixtures. Based on these results, vanillin has been considered as freely soluble in Carbitol and soluble in water. (C) 2015 Elsevier Ltd. All rights reserved.