Abstract
The solubility and various thermodynamic parameters of an antitumor drug brigatinib (BRN) in various ethanol (EtOH) + water (H
O) mixtures were determined in this study. The mole fraction solubility (
) of BRN in various (EtOH + H
O) mixtures including pure EtOH and pure H
O was obtained at
= 298.2–323.2 K and
= 0.1 MPa by adopting a saturation shake flask method. Hansen solubility parameters (HSPs) of BRN, pure EtOH, pure H
O and (EtOH + H
O) mixtures free of BRN were also computed. The
values of BRN were correlated using Van’t Hoff, Apelblat, Yalkowsky–Roseman, Jouyban–Acree and Jouyban–Acree–Van’t Hoff models with mean errors of <2.0%. The maximum and minimum
value of BRN was obtained in pure EtOH (1.43 × 10
at
= 323.2 K) and pure H
O (3.08 × 10
at
= 298.2 K), respectively. The HSP of BRN was also found more closed with that of pure EtOH. The
value of BRN was obtained as increasing significantly with the rise in temperature and increase in EtOH mass fraction in all (EtOH + H
O) mixtures including pure EtOH and pure H
O. The data of apparent thermodynamic analysis showed an endothermic and entropy-driven dissolution of BRN in all (EtOH + H
O) mixtures including pure EtOH and pure H
O.