Abstract
The solubility of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) in supercritical carbon dioxide has been determined at 315,327,334 and 345 K and in the pressure range from 13.2 to 25.1 MPa using an analytical method with a quasi-flow apparatus. Prior to performing these measurements, the method was validated by measuring anthracene solubilities and comparing these with literature values. The molar solubility for Delta(9)-THC ranged from 0.20 to 2.95 x 10(-4). The data were correlated using the Peng-Robinson equation of state in combination with quadratic mixing rules. Deviations between calculated results and the experimental data ranged from 4.1 to 13.3% absolute average relative deviation (AARD). (C) 2009 Elsevier B.V. All rights reserved.