Abstract
In the present investigation, the solubility of metoclopramide hydrochloride (MHCl) in six green solvents, namely water, ethanol, propylene glycol (PG), polyethylene glycol-400 (PEG-400), ethylene glycol (EG), and Transcutol from (298.15 to 338.15) K was measured using an isothermal method. The measured solubilities of MHCl were correlated with the Apelblat equation at (298.15 to 338.15) K. The root-mean-square deviations (rmsd’s) were calculated with the help of experimental and calculated solubility data of MHCl. The rmsd’s were observed in the range of (0.063 to 0.569)·10–3 in all green solvents investigated. Moreover, the correlation coefficients in all green solvents were observed in the range of 0.993 to 0.998. The data of rmsd’s and correlation coefficients indicated good fitting of experimental data with calculated values. At 298.15 K (room temperature), the solubility of MHCl was found to be highest in EG (134.93·10–3 at 298.15 K) followed by water (51.61·10–3 at 298.15 K), Transcutol (48.17·10–3 at 298.15 K), PG (45.57·10–3 at 298.15 K), PEG-400 (41.89·10–3 at 298.15 K), and ethanol (32.88·10–3 at 298.15 K). On the basis of these results, MHCl has been considered as freely soluble in EG, PG, ethanol, and Transcutol, very soluble in water, and soluble in PEG-400.