Abstract
The objective of this research work was to measure the solubility of mycophenolate mofetil (MPM) in ten different pure solvents at temperatures T=298.2K to 318.2K and pressure p=0.1MPa. The solubilities of MPM in mole fraction were obtained maximum in ethyl acetate (9.28×10−2) and minimum in water (4.16×10−6) at “T=318.2K” and similar trends were also observed at each temperature investigated. Higher solute-solvents molecular interactions were observed in MPM-ethyl acetate and MPM-Transcutol. Apparent thermodynamic analysis indicated an endothermic and entropy-driven dissolution of MPM in each solvent investigated.
•Solubility of mycophenolate mofetil (MPM) in different pure solvents was measured.•The mole fraction solubilities of MPM were recorded highest in EA.•Experimental solubilities of MPM were correlated well with computational models.•The dissolution of MPM was recorded as endothermic and entropy-driven.•Solute-solvent molecular interactions were maximum in EA-MPM.