Abstract
In this work, the solubility of poorly water soluble anti-inflammatory drug lornoxicam (LOX) in ten different green solvents such as water, ethanol, 1-butanol, 2-butanol, ethylene glycol (EG), ethyl acetate (EA), isopropanol (IPA), propylene glycol (PG), polyethylene glycol-400 (PEG-400) and 2-(2-ethoxyethoxy) ethanol was measured at T=(298.15 to 323.15) K and p=0.1MPa using an isothermal method. The measured solubility data of LOX were correlated with Apelblat and Van't Hoff models with root mean square deviations in the range of 0.33 to 3.70%. The mole fraction solubility of LOX was observed highest in PEG-400 (8.55×10−3) followed by 2-(2-ethoxyethoxy) ethanol, EG, EA, PG, 2-butanol, 1-butanol, IPA, ethanol and water at T=298.15K. Thermodynamic analysis indicated an endothermic and spontaneous dissolution behavior of LOX in all green solvents.
•Solubility of lornoxicam (LOX) in ten different green solvents was measured.•The solubility of LOX was observed highest in PEG-400.•Experimental solubility data were correlated well with calculated solubility data.•Thermodynamic analysis indicated an endothermic and spontaneous dissolution of LOX.