Abstract
•This study included 50 patients with diabetes mellitus. 20 were type 1, 30 were type 2, and 30 healthy subjects as a control group.•SEPCR and hsCRP are increased in patients with diabetes mellitus type 1 and type 2 when compared to control group.•In type 1 DM, it was found that both sEPCR and BMI were significant predictors of macrovascular complications. In type 2 DM, it was noticed that hsCRP and cholesterol were significant predictors of macrovascular complications. Neither sEPCR nor hsCRP were predictors of microvascular complications in both types of DM.•sEPCR and cholesterol were found to be significant predictors of thrombosis in type 1DM. There were no significant predictors of thrombosis in type 2 DM.
Endothelial dysfunction in diabetes mellitus (DM) is an important factor in the pathogenesis of micro and macrovascular complications. We aimed to measure soluble endothelial protein C receptor (sEPCR) and high sensitivity C reactive protein (hsCRP) levels as markers of endothelial damage in both types of diabetes mellitus and to determine if they can be used as predictors of vascular complications.
Fifty patients with DM, 20 with type 1 and 30 with type 2 as well as 30 healthy subjects were included. All were subjected to measurement of sEPCR and hsCRP by enzyme linked immunosorbent assay.
sEPCR and hsCRP were significantly increased when compared to the control group in both types of DM. sEPCR was a significant predictor of macrovascular complications and thrombosis in type 1 p=0.02, and p=0.015, respectively. hsCRP was a significant predictor of macrovascular complications in type 2 p=0.04.
Patients with type 1 and type 2 DM exhibit higher sEPCR and hsCRP levels compared to healthy controls which suggesting endothelial damage. sEPCR could be used as a predictor of macrovascular complications and thrombosis in type 1 DM, whereas, hsCRP might be used as a predictor of macrovascular complications in type 2 DM.