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Solution-phase synthesis of chiral O-acyl isodipeptides
Journal article   Peer reviewed

Solution-phase synthesis of chiral O-acyl isodipeptides

Mirna El Khatib, Lilibeth Jauregui, Srinivasa R. Tala, Levan Khelashvili and Alan R. Katritzky
MedChemComm, Vol.2(11), pp.1087-1092
01/11/2011

Abstract

Biochemistry & Molecular Biology Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology
O-Acylation of N-Boc-protected-serine and -threonine with N-Pg-(alpha-aminoacyl)benzotriazoles afforded the chiral O-acylated isodipeptides at 23 degrees C in yields of 74-91%.

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