Abstract
The aim of this study was to correlate the solubility of indomethacin (IND) in pure solvents and various ethanol-water mixtures in the temperature range from 293.15 to 318.15 K. The solubility of IND was determined by the shake flask method and resulting data correlated with the modified Apelblat equation. The experimental data of IND were found to correlate well with the modified Apelblat model. The solubility of IND was found to increase with increasing temperature in pure solvents, as well as in ethanol-water mixtures. The mole fraction solubility of IND was highest in pure ethanol (2.50 x 10(-3) at 298.15 K) as compared to pure water (4.48 x 10(-8) at 298.15 K) at each temperature. The values of enthalpy and entropy indicated that the dissolution of IND is an endothermic and entropy-driven process.