Abstract
A sulfonamide is a functional group that serves as a scaffold in both medicinal and synthetic organic chemistry. It is the basis of many sulfa drugs. Several new amino acid-sulfanilamide conjugates were synthesized, and evaluated for its antibacterial and antifungal activity. On the basis of their elementary and spectral evaluations, the structures of the synthesized compounds have been verified. Antibacterial activity of the synthesized compounds (5a-c) was tested against S. aureus, B. subtilis, E. coli, and P. aeruginosa, and antifungal activity were tested against C. albicans and A. niger and compared with the reference drug Gentamycin for antibacterial activity and Miconazole for antifungal activity. All tested compounds showed significant antibacterial and antifungal activity. Amongst all the compounds (5a-c), compound 5a exhibited encouraging antibacterial, and antifungal activities and would be an effective candidate. These compounds also displayed moderate inhibitory activity towards dihydrofolate reductase, reflecting their potential to act as an effective antimicrobial agent.