Abstract
Novel beta-enaminonitrile of 1-(6-phenyl-pyridazin-3-yl)-pyrazole derivative 2 was formed using (6-phenyl-pyridazin-3-yl)-hydrazine (1) and 2-ethoxymethylene-malononitrile. The beta-enaminonitrile derivative 2 was in turn used as precursors for the preparation of 1-(6-phenyl-pyridazin-3-yl)-pyrazoles (3, 9, 11), 1-(6-phenyl -pyridazin-3-yl)-pyrazolo[3,4-d]pyrimidines (4, 5, 6, 7, 8, 13, 14, 15, 16) and some of their corresponding N-acyclic nucleosides (17, 18). All synthesized compounds were tested for their antimicrobial evaluation, and compounds 3, 9, 17, and 18 showed more significant activity than the other tested compounds and some known drugs (standers).