Some of the organic ligand transition metal complexes can serve as potent α-glucosidase inhibitors: in-vitro, kinetics and in-silico studies

Syed Majid Bukhari; Rizwana Sarwar; Asma Zaidi; Majid Ali; Farhan A. Khan; Umar Farooq; Jalal Uddin; Aliya Ibrar; Ajmal Khan; Ahmed Al-Harrasi

doi:10.1080/24701556.2023.2183219

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Some of the organic ligand transition metal complexes can serve as potent α-glucosidase inhibitors: in-vitro, kinetics and in-silico studies

Journal article

Peer reviewed

Some of the organic ligand transition metal complexes can serve as potent α-glucosidase inhibitors: in-vitro, kinetics and in-silico studies

Syed Majid Bukhari, Rizwana Sarwar, Asma Zaidi, Majid Ali, Farhan A. Khan, Umar Farooq, Jalal Uddin, Aliya Ibrar, Ajmal Khan and Ahmed Al-Harrasi

Inorganic and nano-metal chemistry, Vol.ahead-of-print(ahead-of-print), pp.1-8

19/02/2023

DOI: https://doi.org/10.1080/24701556.2023.2183219

Abstract

metal complexes

molecular docking studies

noncompetitive inhibition

α-Glucosidase inhibition

Inhibition potential of synthesized bi-ligand metal complexes of 4-aminoantipyrine Schiff bases (3-14) and mixed-ligand metal complexes of cysteine-moxifloxacin (15-24) were analyzed for their inhibition potential against α-glucosidase and the type of inhibition was assessed by their kinetics and molecular docking studies. The Hg metal complex of cysteine-moxifloxacin (17) showed promising inhibition. Furthermore, the Ag (14), Hg (6) and Cu (4) metal complexes of Schiff base ligand of 4-aminoantipyrine also presented high activity potential. The IC 50 values of these compounds are 2.36 ± 0.14 μM, 48.8 ± 2.20 μM, 189 ± 17.00 μM and 264 ± 10.00 μM, respectively, as compared to standard drug acarbose with IC 50 value of 378.2 ± 0.12 μM. Kinetic studies of compounds (17 and 14) from both series of metal complexes indicated that they are noncompetitive inhibitors of α-glucosidase. Molecular docking studies showed that these compounds accommodate well in the active site of α-glucosidase.

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Title: Some of the organic ligand transition metal complexes can serve as potent α-glucosidase inhibitors: in-vitro, kinetics and in-silico studies
Creators - without role: Syed Majid Bukhari - COMSATS University Islamabad
Rizwana Sarwar - COMSATS University Islamabad
Asma Zaidi - COMSATS University Islamabad
Majid Ali - COMSATS University Islamabad
Farhan A. Khan - COMSATS University Islamabad
Umar Farooq - COMSATS University Islamabad
Jalal Uddin - King Khalid University
Aliya Ibrar - University of Haripur
Ajmal Khan - University of Nizwa
Ahmed Al-Harrasi - University of Nizwa
Publication Details: Inorganic and nano-metal chemistry, Vol.ahead-of-print(ahead-of-print), pp.1-8
Publisher: Taylor & Francis
Identifiers: 9923889008331
Academic Unit: King Khalid University
Language: English
Resource Type: Journal article