Abstract
High-intensity ultrasound can be used to produce novel materials, offering an atypical pathway to recognized products without high bulk temperatures, high pressures, or long reaction times. A highly sensitive and selective robust modified sensor was developed using a composition of electrochemically active strontium metal (Sr) based tungstate interconnected with nafion polymer through a facile sonochemical approach. In addition, multiple parameters are important for sonochemical methods and specifically nanomaterial or electrocatalyst development during the ultrasonic irradiation. Moreover, high-intensity ultrasonic probe (Ti-horn) was used to synthesis of nanomaterial at 50 kHz and 200 W. The SrWO4/nafion was characterized via FESEM, EDX and XRD methods. 8-HD-guanosine (8-hydroxydeoxyguanosine) is one of the major byproduct of deoxyribonucleic acid (DNA) oxidation. The concentrations of 8-HD-guanosine within a cell are a measurement of oxidative stress in body and however its excess level in body causes carcinogenic threats. Therefore, the quantification of 8-HD-guanosine in biological samples with high sensitivity is of great significance. The SrWO4/nafion modified sensor displayed low detection of 14.36 nM and wide linear range (0.025-398.6 mu M), compare to previous reports.